5-HTTLPR

Polymorphism: 5-HTTLPR


Variant Type: Locus
Location: 17q11.2

Factor:
- Symbol: SLC6A4
- Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
- Entrez ID: 6532
- Ensembl ID: ENSG00000108576

Factors:
  • SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 ( 6532 / ENSG00000108576 )


  • Description:

    Alleles can be long (L) or short (S). The long-allele (L/L) genotype of the serotonin transporter-linked gene is more frequent in female centenarians than in male centenarians. Link to longevity not clear. pvalue < 0.05 Genotype frequency were not at HWE P<0.05

    Ethnicity: Australian, Caucasian
    Age of cases: 101.0 ± 0.2
    Shorter lived allele: L/L (only for males)
    Finding: Positive

    Statistics
    - Number of cases/controls: 15 male, 53 female centenarians (cases) (initial)
    - p-value: 0.03
    - Significant: Yes

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: PCR, gel electrophoresis

    Reference:
    22985157: Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians.

    Choice: Clean
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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