LPA isoform

Polymorphism: LPA isoform



Variant Type: Haplotype
Location: 6q26

Factor:
- Symbol: LPA
- Name: lipoprotein, Lp(a)
- Entrez ID: 4018
- Ensembl ID: ENSG00000198670

Factors:

LPA lipoprotein, Lp(a) ( 4018 / ENSG00000198670 )

Description:

Low molecular weight (LMW) apo a phenotypes (protein isoforms) are associated with a shorter lifespan in men but not in women.

Ethnicity: Japanese
Age of cases: 80+
Shorter lived allele: Lp(a)F, Lp(a)B
Finding: Positive

Statistics
- Number of cases/controls: 84 (cases) vs 517 (initial)
- p-value: 0.05 [0.05 (men)]
- Significant: Yes

Study Design
- Study type: Candidate Region/Gene
- Technology: SDS-PAGE, immunoblotting (genotype inferred from protein isoforms)

Reference:
11269751: Decreased longevity in Japanese men, associated with low-molecular-weight apolipoprotein(a) phenotypes.

Choice: Clean
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.

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