rs5981072

Polymorphism: rs5981072
rs5981072 ( SNPedia | 23andMe )

Variant Type: SNP
Location: Xq13.1

Factor:
- Symbol: FOXO4
- Name: forkhead box O4
- Entrez ID: 4303
- Ensembl ID: ENSG00000184481

Factors:

FOXO4 forkhead box O4 ( 4303 / ENSG00000184481 )

Description:

Our results suggest that in Germans [nor Italians], none of the three genes plays a significant role in the ability to reach old age.

p-value = 0.368 (allele)

p-value = 0.976 (genotype)

odds ratio = 0.94 (0.83–1.07) (95% C.I.)

Ethnicity: German
Age of cases: Mean age 98.8
Finding: Negative

Statistics
- Number of cases/controls: 1447 vs 1029 (German) (initial) | 166 vs 216 (Italian) (replication)
- Odds ratio: 0.98
- p-value: 0.976 [0.548 (genotype)]

Study Design
- Classifications: No Age Effect
- Study type: Candidate Region/Gene
- Technology: SNPIex Genotyping System, TaqMan SNP Genotyping Assays, Infinium II Assay-HumanHap 317K duo BeadChip system

Reference:
21388494: Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans.

Choice: Curate
Created: July 29, 2013, 10:19 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.

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