rs1800896

Polymorphism: rs1800896
rs1800896 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 1q32.2

Factor:
- Symbol: IL10
- Name: interleukin 10
- Entrez ID: 3586
- Ensembl ID: ENSG00000136634


Description:

Aim: connection of CVD development with age and IL-10 promotor polymorphism. Several case-control populations in North Italy and Sicily. Several SNPs have been chosen but the most striking data is about mentioned SNP.

Odds ratio = 3.1-3.2

Age of cases: Mean age 67
Shorter lived allele: AA
Longer lived allele: GG

Statistics
- Number of cases/controls: 142 vs 153 (initial)
- Odds ratio: 3.1
- p-value: 0.0003
- Significant: Yes

Study Design
- Classifications: Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR

Reference:
15466015: Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease.

Choice: Dmitrij Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.

Edit (Admin) | Delete

---

Back to top

---