rs1042522

Polymorphism: rs1042522
rs1042522 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 17p13.1

Factor:
- Symbol: TP53
- Name: tumor protein p53
- Entrez ID: 7157
- Ensembl ID: ENSG00000141510

Factors:
  • TP53 tumor protein p53 ( 7157 / ENSG00000141510 )


  • Description:

    TP53*P72 allele negatively influences female life expectancy. Detailed OR information is as follows: Additive model: 0.574, Dominant model: 0.513

    Ethnicity: Italian
    Age of cases: 91+, 73-91
    Shorter lived allele: P
    Finding: Positive

    Statistics
    - Number of cases/controls: 100 very old vs 280 old vs 189 young (initial)
    - Odds ratio: 0.574
    - p-value: 0.006
    - Significant: Yes

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: PCR, restriction digest, gel electrophoresis

    Reference:
    23125046: TP53*P72 allele influences negatively female life expectancy in a population of central Italy: cross-sectional study and genetic-demographic approach analysis.

    Choice: Curate
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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