rs7896005

Polymorphism: rs7896005
rs7896005 ( SNPedia | 23andMe )

Location: 10q21.3

Factor:
- Symbol: SIRT1
- Name: sirtuin 1
- Entrez ID: 23411
- Ensembl ID: ENSG00000096717

Factors:
  • SIRT1 sirtuin 1 ( 23411 / ENSG00000096717 )


  • Description:

    The SIRT1 locus was significantly associated with longevity (P<0.003). The association of the same variant of SIRT1 with longevity was near significant (P<0.07) in a second population. Detailed OR information is as follows: 2.382 (1.355–4.282). 1.334 (0.978–1.824) for replication

    Ethnicity: Caucasian, European
    Age of cases: 90-103, 98+ (replication)
    Shorter lived allele: G

    Statistics
    - Number of cases/controls: 224 vs 293 (initial) | 170 vs 220 (replication)
    - Odds ratio: 2.382
    - p-value: 0.003
    - Significant: Yes

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: Illumina GoldenGate

    Reference:
    21972126: Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity.

    Choice: Curate
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:18 p.m.

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