A significant interaction between REN gene allele 10 and the mitochondrial H haplotype, which may favour longevity, was found. Both genes had been reported to exhibit no effect on survival alone. However, carriers of the two genes have a significantly increased probability of achieving a long life. Detailed OR information is as follows: 3.274 (1.405 ± 7.630)
Ethnicity:Italian Age of cases: 100+ Longer lived allele: REN10 - mtDNA haplogroup H Finding: Positive
Statistics - Number of cases/controls: 157 (initial)
- Odds ratio: 3.274 - Odds ratio type: Longer - p-value:
0.006
- Significant: Yes
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