(+)2019 del

Polymorphism: (+)2019 del

Variant Type: Deletion
Location: 3q27

- Symbol: ADIPOQ10
- Name: adiponectin, C1Q and collagen domain containing
- Entrez ID: 9370
- Ensembl ID: ENSG00000181092

  • ADIPOQ10 adiponectin, C1Q and collagen domain containing ( 9370 / ENSG00000181092 )

  • Description:

    Over-representation of two common variants in Adiponectin gene (ADIPOQ) in male long-lived individuals combined with their independent association with elevated plasma adiponectin levels (in men and women) suggests that their presence may promote increased life span through the regulation of adiponectin production and/or secretion.

    Ethnicity: Ashkenazi Jewish
    Age of cases: 95-105
    Shorter lived allele: A
    Longer lived allele: Del/Del
    Finding: Positive

    - Number of cases/controls: 118 centenarians vs 78 unrelated young (initial)
    - p-value: 0.05 [<0.05]
    - Significant: Yes

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: Taqman, PSQ HS 96A Pyrosequencer

    18511746: Adiponectin levels and genotype: a potential regulator of life span in humans.

    Choice: Clean
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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