rs1805081

Polymorphism: rs1805081
rs1805081 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 18q11.2

Factor:
- Symbol: NPC1
- Name: Niemann-Pick disease, type C1
- Entrez ID: 4864
- Ensembl ID: ENSG00000141458

Factors:
  • NPC1 Niemann-Pick disease, type C1 ( 4864 / ENSG00000141458 )


  • Description:

    rs1805081 is significant associated with longevity in patients with Alzheimer's disease.

    Ethnicity: Polish
    Age of cases: >100
    Shorter lived allele: T
    Longer lived allele: C
    Finding: Positive

    Statistics
    - Number of cases/controls: 152 vs 120 (initial)
    - p-value: 0.007 [0.007]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    18834923: Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population.

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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