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Denigma
»
Lifespan
»
Variants
» Variant = rs1805081
o
|
Admin
Mouse Lifespan Experiments
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)
rs1805081
Polymorphism:
rs1805081
rs1805081
(
SNPedia
|
23andMe
)
Variant Type:
SNP
Location:
18q11.2
Factor:
- Symbol:
NPC1
- Name:
Niemann-Pick disease, type C1
- Entrez ID:
4864
- Ensembl ID:
ENSG00000141458
Factors:
NPC1
Niemann-Pick disease, type C1
(
4864
/
ENSG00000141458
)
Description:
rs1805081 is significant associated with longevity in patients with Alzheimer's disease.
Ethnicity:
Polish
Age of cases:
>100
Shorter lived allele:
T
Longer lived allele:
C
Finding:
Positive
Statistics
- Number of cases/controls:
152 vs 120 (initial)
- p-value:
0.007 [0.007]
- Significant:
Yes
Study Design
- Classifications:
Longevity-Associated
- Study type:
Candidate Region/Gene
- Technology:
PCR
Reference:
18834923: Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population.
Choice:
Curate
Created:
July 2, 2013, 2:54 a.m.
Updated:
Aug. 8, 2014, 1:06 p.m.
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