K153R

Polymorphism: K153R


Variant Type: SNP
Location: 2q32.2

Factor:
- Symbol: MSTN
- Name: myostatin
- Entrez ID: 2660
- Ensembl ID: ENSG00000138379

Factors:
  • MSTN myostatin ( 2660 / ENSG00000138379 )


  • Description:

    The frequency of the variant R allele was significantly higher in centenarians (7.1 %) than in controls (2.7 %) (P=0.001). The odds ratio of being a centenarian if the subject had the R allele was 3.48. Detailed OR information is as follows: 3.48 (1.67–7.28)

    Ethnicity: Italian, Spaniard
    Age of cases: 100–111
    Shorter lived allele: K

    Statistics
    - Number of cases/controls: 156 vs 384 (initial) | 79 vs 316 (replication)
    - Odds ratio: 3.48
    - p-value: 0.001
    - Significant: Yes

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: PCR, single-base extension (SBE)

    Reference:
    23354683: Association of the K153R polymorphism in the myostatin gene and extreme longevity.

    Choice: Curate
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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