rs2476601

Polymorphism: rs2476601
rs2476601 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 1p13.2

Factor:
- Symbol: PTPN22
- Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
- Entrez ID: 26191
- Ensembl ID: ENSG00000134242

Factors:

PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) ( 26191 / ENSG00000134242 )

Description:

Frequency of PTPN22*T1858 carriers does not differ significantly in nona/centenarians and in octogenarians respect to young group. Detailed OR data is as follows: Nona/centenarian males: 1.08 (0.53–2.24), octagenarian males: 0.85 (0.43–1.69). Nona/centenarian females: 0.79 (0.29–2.15), octagenarian females: 0.79 (0.35–1.82). Detailed P-value data is as follows: Nona/centenarian males: 0.853, octagenarian males: 0.722. Nona/centenarian females: 0.799, octagenarian females: 0.663.

Trivial name is 1858 C>T (R620W).

Ethnicity: Italian
Age of cases: Mean age 93
Finding: Negative

Statistics
- Number of cases/controls: 225 vs 278 (initial)
- Odds ratio type: Longer
- p-value: 0.663
- Significant: No

Study Design
- Study type: Candidate Region/Gene
- Technology: PCR and gel electrophoresis

Reference:
21113673: PTPN22 1858C>T (R620W) functional polymorphism and human longevity.

Choice: Clean
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.

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