rs1776180

Polymorphism: rs1776180
rs1776180 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 1q42-q43

Factor:
- Symbol: EXO1
- Name: exonuclease 1
- Entrez ID: 9156
- Ensembl ID: ENSG00000174371

Factors:
  • EXO1 exonuclease 1 ( 9156 / ENSG00000174371 )


  • Description:

    C allele of this promoter SNP (rs1776180) is significantly enriched in female centenarians (German). This finding is replicated in 455 female French centenarians and 109 controls.

    Ethnicity: French, German
    Age of cases: Mean age 101.3
    Shorter lived allele: G
    Longer lived allele: C
    Finding: Positive

    Statistics
    - Number of cases/controls: 395 vs 411 (initial) | 455 vs 109 (replication)
    - Odds ratio: 1.39
    - p-value: 0.01 [<0.01]
    - Significant: Yes

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: SNPlexTM Genotyping System and TaqMan1 SNP Genotyping Assays

    Reference:
    19698732: A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.

    Choice: Curate
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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