FOXO3A, various

Polymorphism: FOXO3A, various



Location: 6q21

Factor:
- Symbol: FOXO3
- Name: forkhead box O3
- Entrez ID: 2309
- Ensembl ID: ENSG00000118689

Factors:

FOXO3 forkhead box O3 ( 2309 / ENSG00000118689 )

Description:

Positive survival effects of FOXO3A and negative effects of FOXO1A largely compensate each other if one carries both, although FOXO3A has a stronger impact. At very advanced ages 92–110, adjusted for various confounders, positive effects of FOXO3A on survival remain statistically significant. Note: CI for OR is 1.61–1.73.

Ethnicity: Chinese
Age of cases: 100+
Finding: Positive

Statistics
- Number of cases/controls: 760 vs 1060 (initial)
- Odds ratio: 1.67
- p-value: 0.0002
- Significant: Yes

Study Design
- Study type: Candidate Region/Gene
- Technology:

Reference:
20884733: Effects of FOXO genotypes on longevity: a biodemographic analysis.

Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.

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