rs1800896

Polymorphism: rs1800896
rs1800896 ( SNPedia | 23andMe )

Location: 1q31-q32

Factor:
- Symbol: IL-10
- Name: interleukin 10
- Entrez ID: 3586
- Ensembl ID: ENSG00000136634

Factors:
  • IL-10 interleukin 10 ( 3586 / ENSG00000136634 )


  • Description:

    Aim: connection of CVD development with age and IL-10 promotor polymorphism. Several case-control populations in North Italy and Sicily. Several SNPs have been chosen but the most striking data is about mentioned SNP.

    odds ratio = 3-7.6 (3.1-3.2)

    Ethnicity: Italian
    Age of cases: Mean age 67
    Shorter lived allele: AA
    Longer lived allele: GG
    Finding: Positive

    Statistics
    - Number of cases/controls: 142 vs 153 (initial)
    - Odds ratio: 3.0
    - p-value: 0.0003 [<0.0003]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    15466015: Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease.

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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