rs1887922

Polymorphism: rs1887922
rs1887922 ( SNPedia | 23andMe )

Location: 10q23-q25

Factor:
- Symbol: IDE
- Name: insulin-degrading enzyme
- Entrez ID: 3416
- Ensembl ID: ENSG00000119912

Factors:

IDE insulin-degrading enzyme ( 3416 / ENSG00000119912 )

Description:

Change in IDE genotype frequency with advancing age appears to be occurring only in men. Homozygous genotype appears to be detrimental. Detailed OR data is as follows: 2.021 (1.365–2.991)

Ethnicity: Australian, Caucasian
Age of cases: Mixed

Statistics
- Number of cases/controls: 829 vs 1033 (initial)
- Odds ratio: 2.021
- p-value: 0.0004
- Significant: Yes

Study Design
- Study type: Candidate Region/Gene
- Technology: Dynamic allele specific hybridization (DASH)

Reference:
18448515: Evidence that the gene encoding insulin degrading enzyme influences human lifespan.

Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.

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