rs1042719

Polymorphism: rs1042719
rs1042719 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 5q31-q32

Factor:
- Symbol: ADRB2
- Name: adrenergic, beta-2-, receptor, surface
- Entrez ID: 154
- Ensembl ID: ENSG00000169252

Factors:

ADRB2 adrenergic, beta-2-, receptor, surface ( 154 / ENSG00000169252 )

Description:

SNP is G/C. Linked to longevity only in men. Combined studies OR=1.28 (1.57 in males)

Ethnicity: Chinese
Age of cases: Mean age 102.1±0.20
Shorter lived allele: G
Longer lived allele: C
Finding: Positive

Statistics
- Number of cases/controls: 384 vs 384 (initial) | 579 vs 644 (replication)
- Odds ratio: 1.29
- p-value: 1.29 [0.014 (0.012 in males)]
- Significant: Yes

Study Design
- Classifications: Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Protocol of BigDye v1.1 kit and an ABI 3130XL sequencing system (Applied Biosystems)

Reference:
23020224: Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.

Choice: Curate
Created: July 2, 2013, 2:48 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.

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