rs10014396

Polymorphism: rs10014396
rs10014396 ( SNPedia | 23andMe )

Location: 4q21

Factor:
- Symbol: SNCA
- Name: synuclein, alpha (non A4 component of amyloid precursor)
- Entrez ID: 6622
- Ensembl ID: ENSG00000145335

Factors:
  • SNCA synuclein, alpha (non A4 component of amyloid precursor) ( 6622 / ENSG00000145335 )


  • Description:

    rs10014396 and rs3775439 in strong LD=0.84. the population sample was subdivided into 7 age-classes

    Ethnicity: Caucasian
    Age of cases: >90 (oldest age group)
    Shorter lived allele: C

    Statistics
    - Number of cases/controls: 769 total (see notes) (initial)
    - p-value: 0.021 [0.021]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: genotyped on a Sequenom MassArray iPLEX platform

    Reference:
    22912757: Evaluation of the role of SNCA variants in survival without neurological disease.

    Choice: Curate
    Created: July 2, 2013, 2:48 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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