rs422858

Polymorphism: rs422858
rs422858 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 3q24

Factor:
- Symbol: AGTR1
- Name: angiotensin II receptor, type 1
- Entrez ID: 185
- Ensembl ID: ENSG00000144891

Factors:

AGTR1 angiotensin II receptor, type 1 ( 185 / ENSG00000144891 )

Description:

The two polymorphisms (rs422858 and rs275653) are in complete LD, therefore p-value/signf./OR refer to both of them. Polymorphism is a dinucleotide change (AG/ CC). The results (p-value/signf./OR) shown here refer to the data combined for the Italian (initial study) and Japanese (replication study). P value was calculated under a recessive model (GG vs. AA+AG)

Ethnicity: Italian
Age of cases: 99-106 (mean 100.9±1.7)
Shorter lived allele: AG
Longer lived allele: CC
Finding: Positive

Statistics
- Number of cases/controls: 173 vs 376 (initial)
- Odds ratio: 3.57
- p-value: 0.007 [0.007]
- Significant: Yes

Study Design
- Classifications: Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Sequenced in ABI 3730 DNA analyser (Applied Biosystems)

Reference:
22569962: Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity.

Choice: Curate
Created: July 2, 2013, 2:48 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.

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