A-3826G (rs1800592) - C-3740A

Polymorphism: A-3826G (rs1800592) - C-3740A

(rs1800592) ( SNPedia | 23andMe )



Variant Type: Haplotype
Location: 4q28-q31

Factor:
- Symbol: UCP1
- Name: uncoupling protein 1 (mitochondrial, proton carrier)
- Entrez ID: 7350
- Ensembl ID: ENSG00000109424

Factors:
  • UCP1 uncoupling protein 1 (mitochondrial, proton carrier) ( 7350 / ENSG00000109424 )

  • Ethnicity: Italian
    Age of cases: >91
    Shorter lived allele: G-A
    Finding: Positive

    Statistics
    - Number of cases/controls: 236 vs 741 (initial)
    - Odds ratio: 0.811
    - p-value: 0.014 [0.014]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    21827845: Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity.

    Choice: Clean
    Created: July 2, 2013, 2:48 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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