rs10903420

Polymorphism: rs10903420
rs10903420 ( SNPedia | 23andMe )

Location: 10p15.3

Factor:
- Symbol: ADARB2
- Name: adenosine deaminase, RNA-specific, B2
- Entrez ID: 105
- Ensembl ID: ENSG00000185736

Factors:
  • ADARB2 adenosine deaminase, RNA-specific, B2 ( 105 / ENSG00000185736 )


  • Description:

    Shorter-lived allele column - this is actually the "Risk" allele for the Odds Ratio.There were 3 replications to the findings!

    Ethnicity: Northern European
    Age of cases: 96–119 (median: 103)
    Shorter lived allele: AA

    Statistics
    - Number of cases/controls: 877 vs 1808 (initial) | Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538. (replication)
    - Odds ratio: 1.28
    - p-value: 0.0048 [0.0048]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Technology: genomic DNA was analyzed on the Illumina 370 CNV chip

    Reference:
    20011587: RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.

    Choice: Curate
    Created: July 2, 2013, 2:47 a.m.
    Updated: Aug. 10, 2014, 12:02 a.m.

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