Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.

Authors: Dong, Meng-Qiu; Venable, John D; Au, Nora; Xu, Tao; Park, Sung Kyu; Cociorva, Daniel; Johnson, Jeffrey R; Dillin, Andrew; Yates, John R 3rd
Year: 2007
Journal: Science
Abstract: DAF-2, an insulin receptor-like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage and aging. In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin.
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Created on Nov. 5, 2012, 5:59 p.m.
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Integrated: False

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Species: Nematode

Experiments: 0
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