Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.

Authors: Steinkraus KA; Smith ED; Davis C; Carr D; Pendergrass WR; Sutphin GL; Kennedy BK; Kaeberlein M
Year: 2008
Journal: Aging cell
Abstract: Dietary restriction increases lifespan and slows the onset of age-associated disease in organisms from yeast to mammals. In humans, several age-related diseases are associated with aberrant protein folding or aggregation, including neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases. We report here that dietary restriction dramatically suppresses age-associated paralysis in three nematode models of proteotoxicity. Similar to its longevity-enhancing properties, dietary restriction protects against proteotoxicity by a mechanism distinct from reduced insulin/IGF-1-like signaling. Instead, the heat shock transcription factor, hsf-1, is required for enhanced thermotolerance, suppression of proteotoxicity, and lifespan extension by dietary restriction. These findings demonstrate that dietary restriction confers a general protective effect against proteotoxicity and promotes longevity by a mechanism involving hsf-1.


Created on Nov. 5, 2012, 5:58 p.m.
Not linked
Integrated: False

No notes
Species: Nematode

Experiments: 0
  • sams-1 RNAi
  • eat-2 mutation

  • Edit study (Admin) | Add experiment to study (Admin) | Delete study

    Comment on This Data Unit