Neurosecretory control of aging in Caenorhabditis elegans.

Authors: Ailion, M; Inoue, T; Weaver, C I; Holdcraft, R W; Thomas, J H
Year: 1999
Journal: Proc Natl Acad Sci U S A
Abstract: In the nematode Caenorhabditis elegans, an insulin receptor signaling pathway regulates adult life span and developmental arrest at the dauer larval stage. Here we show that the unc-64 and unc-31 genes also function in this pathway. These two genes are involved in mediating Ca2+-regulated secretion. Mutations in unc-64 and unc-31 increase adult life span and cause constitutive dauer formation. Both phenotypes are suppressed by mutations in daf-16, which also suppresses other mutations in this pathway. We present evidence that the site of action of unc-64 is neuronal, suggesting that a neurosecretory signal regulates life span and dauer formation.
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Created on Nov. 5, 2012, 5:58 p.m.
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Species: Nematode

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