Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans.

Authors: Fujii M; Tanaka N; Miki K; Hossain MN; Endoh M; Ayusawa D
Year: 2005
Journal: Bioscience, biotechnology, and biochemistry
Abstract: To analyze the relationship between resistance to oxidative stress and longevity, we isolated three novel paraquat-resistant mutants, mev-5, mev-6, and mev-7, from the nematode Caenorhabditis elegans. They all showed the Dyf (defective in dye filling) phenotype, but not always resistance to heat or UV. Life-span extension was observed only in the mev-5 mutant at 26 degrees C. These results indicate that longevity is uncoupled with the phenotype of paraquat resistance.
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Created on Nov. 5, 2012, 5:58 p.m.
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Species: Nematode

Experiments: 0
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