Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.

Authors: Ewbank JJ; Barnes TM; Lakowski B; Lussier M; Bussey H; Hekimi S
Year: 1997
Journal: Science (New York, N.Y.)
Abstract: Mutations in the Caenorhabditis elegans gene clk-1 affect biological timing and extend longevity. The gene clk-1 was identified, and the cloned gene complemented the clk-1 phenotypes and restored normal longevity. The CLK-1 protein was found to be conserved among eukaryotes, including humans, and structurally similar to the yeast metabolic regulator Cat5p (also called Coq7p). These proteins contain a tandem duplication of a core 82-residue domain. clk-1 complemented the phenotype of cat5/coq7 null mutants, demonstrating that clk-1 and CAT5/COQ7 share biochemical function and that clk-1 acts at the level of cellular physiology.
Reference

Integration:

Created on Nov. 5, 2012, 5:56 p.m.
Not linked
Integrated: False

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Species: Nematode

Experiments: 0
Interventions:

clk-1 mutation

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