Two neurons mediate diet-restriction-induced longevity in C. elegans.

Authors: Bishop, Nicholas A; Guarente, Leonard
Year: 2007
Journal: Nature
Abstract: Dietary restriction extends lifespan and retards age-related disease in many species and profoundly alters endocrine function in mammals. However, no causal role of any hormonal signal in diet-restricted longevity has been demonstrated. Here we show that increased longevity of diet-restricted Caenorhabditis elegans requires the transcription factor gene skn-1 acting in the ASIs, a pair of neurons in the head. Dietary restriction activates skn-1 in these two neurons, which signals peripheral tissues to increase metabolic activity. These findings demonstrate that increased lifespan in a diet-restricted metazoan depends on cell non-autonomous signalling from central neuronal cells to non-neuronal body tissues, and suggest that the ASI neurons mediate diet-restriction-induced longevity by an endocrine mechanism.
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Created on Nov. 5, 2012, 5:55 p.m.
Not linked
Integrated: False

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Species: Nematode

Experiments: 0
Interventions:

daf-2 mutation

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