14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans.
Authors: Araiz C; Château MT; Galas S Year: 2008 Journal: Experimental gerontology Abstract: Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms. Reference
Integration:
Created on Nov. 5, 2012, 5:54 p.m. Not linked Integrated: False
Comment on This Data Unit