High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction.

Authors: Kaeberlein M; Andalis AA; Fink GR; Guarente L
Year: 2002
Journal: Molecular and cellular biology
Abstract: Calorie restriction (CR) extends life span in many different organisms, including mammals. We describe here a novel pathway that extends the life span of Saccharomyces cerevisiae mother cells but does not involve a reduction in caloric content of the media, i.e., there is growth of yeast cells in the presence of a high concentration of external osmolytes. Like CR, this longevity-promoting response to high osmolarity requires SIR2, suggesting a common mechanism of life span regulation. Genetic and microarray analysis indicates that high osmolarity extends the life span by activating Hog1p, leading to an increase in the biosynthesis of glycerol from glycolytic intermediates. This metabolic shift likely increases NAD levels, thereby activating Sir2p and promoting longevity.
Reference

Integration:

Created on Nov. 5, 2012, 4:44 p.m.
Not linked
Integrated: False

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Species: Budding yeast

Experiments: 0
Interventions:

GPD1 deletion

MSN2 MSN4 double mutation

HOG1 deletion

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