Ascorbate restores lifespan of superoxide-dismutase deficient yeast.

Authors: Krzepiłko A; Swieciło A; Wawryn J; Zadrag R; Kozioł S; Bartosz G; Biliński T
Year: 2004
Journal: Free radical research
Abstract: Yeast (Saccharomyces cerevisiae) mutants lacking CuZn-superoxide dismutase (CuZnSOD) are hypersensitive to oxygen and have significantly decreased replicative life span. Both these defects can be ameliorated by exogenous ascorbate. The effect of ascorbate on life span is complicated by auto-oxidation of its compound in the medium. If negative effects of auto-oxidation are prevented by exchange of the medium, ascorbate prolongs not only mean but also maximal replicative life span of the yeast in the atmosphere of air and of pure oxygen. These results demonstrate that life span shortening due to the lack of a vital antioxidant enzyme can be ameliorated by a low-molecular weight antioxidant.
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Created on Nov. 5, 2012, 4:46 p.m.
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Species: Budding yeast

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