Involvement of Drosophila Sir2-like genes in the regulation of life span.

Authors: Kusama S; Ueda R; Suda T; Nishihara S; Matsuura ET
Year: 2006
Journal: Genes & genetic systems
Abstract: In Drosophila melanogaster, the Sir2 gene and four Sir2-like genes have been found to be homologous to yeast SIR2 genes. To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons and ubiquitous silencing of the Sir2-like genes shortened life spans. The effects were severer at 28 degrees C than at 25 degrees C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of life span in Drosophila.
Reference

Integration:

Created on May 14, 2013, 9:10 p.m.
Not linked
Integrated: False

No notes
Species: Fruit fly

Experiments: 0
Interventions:

Sirt6 RNAi

Sir2 mutation

Sir2 RNAi

Sirt2 RNAi

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