The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis.

Authors: Lim DH; Oh CT; Lee L; Hong JS; Noh SH; Hwang S; Kim S; Han SJ; Lee YS
Year: 2011
Journal: FEBS letters
Abstract: Small non-coding RNAs regulate gene expression in a sequence-specific manner. In Drosophila, Dicer-2 (Dcr-2) functions in the biogenesis of endogenous small interfering RNAs (endo-siRNAs). We identified 21 distinct proteins that exhibited a >/= 1.5-fold change as a consequence of loss of dcr-2 function. Most of these were metabolic genes implicated in stress resistance and aging. dcr-2 Mutants had reduced lifespan and were hypersensitive to oxidative, endoplasmic reticulum, starvation, and cold stresses. Furthermore, loss of dcr-2 function led to abnormal lipid and carbohydrate metabolism. Our results suggest roles for the endo-siRNA pathway in metabolic regulation and defense against stress and aging in Drosophila.
Reference

Integration:

Created on Nov. 30, 2012, 2:03 p.m.
Not linked
Integrated: False

No notes
Species: Fruit fly

Experiments: 0
Interventions:

Dcr-2 mutation

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