Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

Authors: Orr WC; Sohal RS
Year: 1994
Journal: Science (New York, N.Y.)
Abstract: The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time, a lower amount of protein oxidative damage, and a delayed loss in physical performance. Results provide direct support for the free radical hypothesis of aging.
Reference

Integration:

Created on Nov. 6, 2012, 11:57 a.m.
Not linked
Integrated: False

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Species: Fruit fly

Experiments: 0
Interventions:

Overexpression of Cat and Sod1

Cat overexpression

Sod overexpression

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