Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.

Authors: Clancy DJ; Gems D; Harshman LG; Oldham S; Stocker H; Hafen E; Leevers SJ; Partridge L
Year: 2001
Journal: Science (New York, N.Y.)
Abstract: The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.
Reference

Integration:

Created on Nov. 6, 2012, 11:55 a.m.
Not linked
Integrated: False

No notes
Species: Fruit fly

Experiments: 0
Interventions:

Heterzygous chico mutation

Pi3K92E mutation

InrGC25/InrE19 transheterozygous mutation

Akt1 mutation

Homozygous chico mutation

ovo mutation

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