A systematic RNAi screen for longevity genes in C. elegans.

Authors: Hamilton B; Dong Y; Shindo M; Liu W; Odell I; Ruvkun G; Lee SS
Year: 2005
Journal: Genes & development
Abstract: We report here the first genome-wide functional genomic screen for longevity genes. We systematically surveyed Caenorhabditis elegans genes using large-scale RNA interference (RNAi), and found that RNAi inactivation of 89 genes extend C. elegans lifespan. Components of the daf-2/insulin-like signaling pathway are recovered, as well as genes that regulate metabolism, signal transduction, protein turnover, and gene expression. Many of these candidate longevity genes are conserved across animal phylogeny. Genetic interaction analyses with the new longevity genes indicate that some act upstream of the daf-16/FOXO transcription factor or the sir2.1 protein deacetylase, and others function independently of daf-16/FOXO and sir2.1, and might define new pathways to regulate lifespan.
Reference

Integration:

Created on Nov. 6, 2012, 11:27 a.m.
Not linked
Integrated: False

No notes
Species: Nematode

Experiments: 0
Interventions:

hcf-1 RNAi

rnf-5 RNAi

ubh-4 RNAi

C18E9.4 RNAi

inx-14 RNAi

F35D2.3 RNAi

F40F8.5 RNAi

spt-4 RNAi

cec-1 RNAi

mecr-1 RNAi

nuo-2 RNAi

drr-1 RNAi

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