Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.

Authors: Sinclair DA; Mills K; Guarente L
Year: 1997
Journal: Science (New York, N.Y.)
Abstract: The SGS1 gene of yeast encodes a DNA helicase with homology to the human WRN gene. Mutations in WRN result in Werner's syndrome, a disease with symptoms resembling premature aging. Mutation of SGS1 is shown to cause premature aging in yeast mother cells on the basis of a shortened life-span and the aging-induced phenotypes of sterility and redistribution of the Sir3 silencing protein from telomeres to the nucleolus. Further, in old sgs1 cells the nucleolus is enlarged and fragmented-changes that also occur in old wild-type cells. These findings suggest a conserved mechanism of cellular aging that may be related to nucleolar structure.
Reference

Integration:

Created on Nov. 5, 2012, 4:46 p.m.
Not linked
Integrated: False

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Species: Budding yeast

Experiments: 0
Interventions:

HAP5 deletion

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