Extended life-span and stress resistance in the Drosophila mutant methuselah.

Authors: Lin YJ; Seroude L; Benzer S
Year: 1998
Journal: Science (New York, N.Y.)
Abstract: Toward a genetic dissection of the processes involved in aging, a screen for gene mutations that extend life-span in Drosophila melanogaster was performed. The mutant line methuselah (mth) displayed approximately 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator. The mth gene predicted a protein with homology to several guanosine triphosphate-binding protein-coupled seven-transmembrane domain receptors. Thus, the organism may use signal transduction pathways to modulate stress response and life-span.
Reference

Integration:

Created on Nov. 6, 2012, 11:12 a.m.
Not linked
Integrated: False

No notes
Species: Fruit fly

Experiments: 0
Interventions:

mth mutation

Edit study (Admin) | Add experiment to study (Admin) | Delete study

---

Back to top

---