New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound.

Authors: Nakaya S; Mizuno S; Ishigami H; Yamakawa Y; Kawagishi H; Ushimaru T
Year: 2012
Journal: Bioscience, biotechnology, and biochemistry
Abstract: The chronological lifespan (CLS) of budding yeast is a model for the aging of post-mitotic cells in higher eukaryotes. We report here the development of a new method to assess yeast CLS. The new assay is simple, convenient and labor-saving. We applied this new method to screen natural compounds isolated from mushrooms and discovered beauveriolide I as a potent anti-aging agent.
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Created on Nov. 6, 2012, 11:06 a.m.
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Integrated: False

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Species: Budding yeast

Experiments: 0
Interventions:

Beauveriolide I treatment

Rapamycin treatment

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