Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
Authors: Streeper RS; Grueter CA; Salomonis N; Cases S; Levin MC; Koliwad SK; Zhou P; Hirschey MD; Verdin E; Farese RV Jr Year: 2012 Journal: Aging Abstract: Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Female DGAT1-deficient mice were protected from age-related increases in body fat, tissue triglycerides, and inflammation in white adipose tissue. This protection was accompanied by increased mean and maximal life spans of ~25% and ~10%, respectively. Middle-agedDgat1-/- mice exhibited several features associated with longevity, including decreased levels of circulating insulin growth factor 1 (IGF1) and reduced fecundity. Thus, deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction. Reference
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Created on Nov. 6, 2012, 10:57 a.m. Not linked Integrated: False
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