Extended longevity in mice lacking the insulin receptor in adipose tissue.

Authors: Blüher M; Kahn BB; Kahn CR
Year: 2003
Journal: Science (New York, N.Y.)
Abstract: Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals. In some organisms, this has been associated with a decreased fat mass and alterations in insulin/insulin-like growth factor 1 (IGF-1) pathways. To further explore these associations with enhanced longevity, we studied mice with a fat-specific insulin receptor knockout (FIRKO). These animals have reduced fat mass and are protected against age-related obesity and its subsequent metabolic abnormalities, although their food intake is normal. Both male and female FIRKO mice were found to have an increase in mean life-span of approximately 134 days (18%), with parallel increases in median and maximum life-spans. Thus, a reduction of fat mass without caloric restriction can be associated with increased longevity in mice, possibly through effects on insulin signaling.
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Created on Nov. 6, 2012, 10:52 a.m.
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Species: House mouse

Experiments: 0
Interventions:

Heterozyogous fat-specific Insr knockout (FIRKO)

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