Studies Archive

PMIDTitleExperimentsIntegrated
#23994476 Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression.
0
False
#20404021 Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging.
0
False
#21471153 The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.
0
False
#18335035 SirT1 regulates energy metabolism and response to caloric restriction in mice.
0
False
#23695394 A Dwarf Mouse Model With Decreased GH/IGF-1 Activity That Does Not Experience Life-Span Extension: Potential Impact of Increased Adiposity, Leptin, and Insulin With Advancing Age.
0
False
#11039916 The effect of different light regimes on adult life span in Drosophila melanogaster is partly mediated through reproductive output.
0
False
#23698443 Mitonuclear protein imbalance as a conserved longevity mechanism.
0
False
#23691220 Dietary Restriction Depends on Nutrient Composition to Extend Chronological Lifespan in Budding Yeast Saccharomyces cerevisiae.
0
False
#22055505 Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.
0
False
#15695762 Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors.
0
False
#18809674 Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster.
0
False
#19209226 Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
0
False
#18478054 An RGS-containing sorting nexin controls Drosophila lifespan.
0
False
#21111239 FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging.
0
False
#21826223 Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.
0
False
#18678867 Life span extension and neuronal cell protection by Drosophila nicotinamidase.
0
False
#18775584 Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity.
0
False
#18083727 The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function.
0
False
#18208580 Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila.
0
False
#21776417 Loco signaling pathway in longevity.
0
False
#18494863 The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies.
0
False
#21029723 dGIPC is required for the locomotive activity and longevity in Drosophila.
0
False
#18275960 Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance.
0
False
#15346199 Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression.
0
False
#19011900 Adult-specific over-expression of the Drosophila genes magu and hebe increases life span and modulates late-age female fecundity.
0
False
#18258192 Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila.
0
False
#20589912 Life-span phenotypes of elav and Rbp9 in Drosophila suggest functional cooperation of the two ELAV-family protein genes.
0
False
#20018689 Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.
0
False
#18221418 Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.
0
False
#17999718 Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion.
0
False
#19302370 Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans.
0
False
#18665908 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila.
0
False
#16054055 Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.
0
False
#15133470 The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila.
0
False
#17159295 Involvement of Drosophila Sir2-like genes in the regulation of life span.
0
False
#23648059 Prolonged Lifespan with Enhanced Exploratory Behavior in Mice Overexpressing the Oxidized Nucleoside Triphosphatase hMTH1.
0
False
#23636330 Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH.
0
False
#22405073 Pten positively regulates brown adipose function, energy expenditure, and longevity.
0
False
#23468654 Roles of the Developmental Regulator unc-62/Homothorax in Limiting Longevity in Caenorhabditis elegans.
0
False
#20017609 Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster.
0
False
#20976250 Lifespan extension by preserving proliferative homeostasis in Drosophila.
0
False
#21296648 The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation.
0
False
#22982350 Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice.
0
False
#23023872 Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
0
False
#23105098 Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis.
0
False
#23055713 Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease.
0
False
#23104101 Seven sirtuins for seven deadly diseases of aging.
0
False
#23293221 Resveratrol protects against age-associated infertility in mice.
0
False
#22960591 Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri.
0
False
#23242337 [Reversal of aging and lifespan elongation : Current biomedical key publications and the implications for geriatrics.]
0
False
#23363784 Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.
0
False
#21215371 The cell-non-autonomous nature of electron transport chain-mediated longevity.
0
False
#17516143 The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice.
0
False
#23349740 Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.
0
False
#23300461 Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation.
0
False
#23300685 Anti-Inflammatory Lactobacillus rhamnosus CNCM I-3690 Strain Protects against Oxidative Stress and Increases Lifespan in Caenorhabditis elegans.
0
False
#11021802 Regulation of C. elegans life-span by insulinlike signaling in the nervous system.
0
False
#16441844 Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans.
0
False
#23291977 Sesamin extends the mean lifespan of fruit flies.
0
False
#23291976 Mechanism underlying prolongevity induced by bifidobacteria in Caenorhabditis elegans.
0
False
#17506834 Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol.
0
False
#16784770 Preadaptation to efficient respiratory maintenance is essential both for maximal longevity and the retention of replicative potential in chronologically ageing yeast.
0
False
#22871733 pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast.
0
False
#23235143 Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae.
0
False
#14583653 Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice.
0
False
#16278235 Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.
0
False
#18729070 Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23.
0
False
#16436465 Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.
0
False
#17183314 A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
0
False
#11950998 Premature aging in mice deficient in DNA repair and transcription.
0
False
#17872905 Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice.
0
False
#16675955 ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.
0
False
#17143283 Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.
0
False
#14690422 Caveolin-1 null (-/-) mice show dramatic reductions in life span.
0
False
#16144468 Oxidative stress and aging: catalase is a longevity determinant enzyme.
0
False
#17188333 Caspase-2 deficiency enhances aging-related traits in mice.
0
False
#16476774 Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.
0
False
#12533509 Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.
0
False
#17420720 Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.
0
False
#17360389 Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice.
0
False
#19620979 A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.
0
False
#12540856 Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
0
False
#8917548 Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
0
False
#8843194 Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.
0
False
#2394907 Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice.
0
False
#5723482 Free radical theory of aging: effect of free radical reaction inhibitors on the mortality rate of male LAF mice.
0
False
#16847346 Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock.
0
False
#17227869 Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
0
False
#6334792 Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice.
0
False
#9972869 Prolongation of life in an experimental model of aging in Drosophila melanogaster.
0
False
#23246004 dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner.
0
False
#23271974 The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegans.
0
False
#23247094 Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans.
1
False
#23239738 A steroid receptor-microRNA switch regulates life span in response to signals from the gonad.
0
False
#18486188 Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span.
0
False
#23242215 Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
3
False
#22935001 Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain.
0
False
#15754958 [Effect of antidiabetic drug diabenol on parameters of biological age, life span and tumor development in NMRI and HER-2/neu mice].
0
False
#23077661 Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila.
0
False
#20304770 Metformin supplementation and life span in Fischer-344 rats.
0
False
#21164223 Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice.
0
False
#16224592 Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice.
0
False
#21386129 If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
0
False
#20090912 Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.
0
False
#18728386 Metformin slows down aging and extends life span of female SHR mice.
1
False
#16125352 Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
1
False
#12707040 Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.
0
False
#19741171 Vitamin C restores healthy aging in a mouse model for Werner syndrome.
0
False
#15115755 A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint.
0
False
#23075628 Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.
0
False
#21637768 Polyhydroxy fullerenes (fullerols or fullerenols): beneficial effects on growth and lifespan in diverse biological models.
0
False
#17079053 A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice.
0
False
#15451059 A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties.
0
False
#22498298 The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene.
1
True
#20550518 Longevity is not influenced by prenatal programming of body size.
0
False
#12725740 The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism.
1
False
#21889502 The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis.
0
False
#21810936 Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans.
4
False
#15192154 Long-lived Drosophila with overexpressed dFOXO in adult fat body.
0
False
#12399591 Timing requirements for insulin/IGF-1 signaling in C. elegans.
0
False
#22107964 Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.
0
False
#23185716 Minocycline effect on life and health span of Drosophila melanogaster.
2
True
#17637672 Delayed ageing through damage protection by the Arf/p53 pathway.
0
False
#23173729 A metabolic signature for long-life in the c. Elegans mit mutants.
0
False
#20732954 Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism.
0
False
#23172930 Absence of Cardiotrophin 1 Is Associated With Decreased Age-Dependent Arterial Stiffness and Increased Longevity in Mice.
1
False
#23172144 An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
4
True
#23167605 Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
6
False
#22559237 Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension.
0
False
#11095759 Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.
0
False
#20607427 Flies selected for longevity retain a young gene expression profile.
0
False
#23106705 GENOMIC BASIS OF AGING AND LIFE-HISTORY EVOLUTION IN DROSOPHILA MELANOGASTER.
0
False
#22482727 The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO.
0
False
#23097426 Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans.
0
False
#22970296 Metabolic rate regulates L1 longevity in C. elegans.
0
False
#20974969 DDS, 4,4'-diaminodiphenylsulfone, extends organismic lifespan.
0
False
#5961480 The effect of mating status, sex and genotype on longevity in Drosophila melanogaster.
0
False
#23133668 Extension of yeast chronological lifespan by methylamine.
0
False
#12820979 Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone.
0
False
#23121290 Modulation of Methuselah Expression Targeted to Drosophila Insulin-producing Cells Extends Life and Enhances Oxidative Stress Resistance.
0
False
#22997544 Overexpression of Fatty-Acid-β-Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster.
1
True
#16434470 Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.
0
False
#21123740 Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.
0
False
#19747233 The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet.
0
False
#21876806 Lifespan and glucose metabolism in insulin receptor mutant mice.
0
False
#10875265 Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.
0
False
#8108730 Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.
0
False
#17103233 Superoxide dismutase activities in long-lived Drosophila melanogaster females: chico1 genotypes and dietary dilution.
0
False
#12743125 Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster.
0
False
#20923705 Expression of multiple copies of mitochondrially targeted catalase or genomic Mn superoxide dismutase transgenes does not extend the life span of Drosophila melanogaster.
0
False
#16387864 Involvement of Drosophila uncoupling protein 5 in metabolism and aging.
0
False
#17272684 Regulation of Drosophila life span by olfaction and food-derived odors.
0
False
#11951037 Dietary restriction in long-lived dwarf flies.
0
False
#11292874 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
0
False
#19461873 HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans.
0
False
#15186745 Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
3
False
#12459580 Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.
0
False
#19851477 dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster.
0
False
#15520384 Sir2 mediates longevity in the fly through a pathway related to calorie restriction.
0
False
#19470468 Long-lived Indy and calorie restriction interact to extend life span.
0
False
#17571923 No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects.
0
False
#12626742 Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies.
0
False
#11118146 Extended life-span conferred by cotransporter gene mutations in Drosophila.
0
False
#15175753 Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body.
0
False
#16055649 Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.
0
False
#16303568 Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span.
0
False
#19747824 Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain.
0
False
#19968629 Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila.
0
False
#19804760 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.
0
False
#20195512 Molecular evolution and functional characterization of Drosophila insulin-like peptides.
0
False
#21930912 Increased transsulfuration mediates longevity and dietary restriction in Drosophila.
0
False
#22348084 Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.
0
False
#22653599 Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan.
0
False
#18067683 Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes.
0
False
#12882325 Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background.
0
False
#18285659 Hyperoxia exposure induced hormesis decreases mitochondrial superoxide radical levels via Ins/IGF-1 signaling pathway in a long-lived age-1 mutant of Caenorhabditis elegans.
0
False
#19553937 A conserved ubiquitination pathway determines longevity in response to diet restriction.
0
False
#19883616 Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.
0
False
#17023606 Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction.
0
False
#19924292 Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling.
0
False
#17096674 Dietary deprivation extends lifespan in Caenorhabditis elegans.
0
False
#17081160 Lifespan extension in Caenorhabditis elegans by complete removal of food.
0
False
#19229346 Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans.
0
False
#19239417 Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans.
0
False
#9789046 The genetics of caloric restriction in Caenorhabditis elegans.
0
False
#19783783 Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.
0
False
#21040400 Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.
0
False
#16387300 Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons.
0
False
#21334311 The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.
0
False
#22132200 The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans.
0
False
#21562563 N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.
0
False
#18662544 An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans.
0
False
#19043800 Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.
0
False
#22216122 Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.
0
False
#20844315 Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans.
0
False
#15767565 JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
0
False
#18832074 SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
0
False
#17266678 A steroid hormone that extends the lifespan of Caenorhabditis elegans.
0
False
#22359667 C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling.
0
False
#18202391 Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity.
0
False
#20041217 TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging.
0
False
#21151885 A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.
0
False
#15998808 A systematic RNAi screen for longevity genes in C. elegans.
0
False
#12845331 Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.
0
False
#9768365 Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene.
0
False
#19293945 A human protein interaction network shows conservation of aging processes between human and invertebrate species.
0
False
#10617200 Regulation of lifespan by sensory perception in Caenorhabditis elegans.
0
False
#16782295 Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein.
0
False
#15688016 Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.
0
False
#22585399 Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.
0
False
#22560223 TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
0
False
#1448167 Production of sperm reduces nematode lifespan.
0
False
#12447374 A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.
0
False
#8247153 A C. elegans mutant that lives twice as long as wild type.
0
False
#15905404 Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
0
False
#22574120 C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline.
0
False
#18828672 Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.
0
False
#12958363 Autophagy genes are essential for dauer development and life-span extension in C. elegans.
0
False
#8034612 Divergent roles of RAS1 and RAS2 in yeast longevity.
0
False
#8900272 Dwarf mice and the ageing process.
0
False
#22737090 An engineering approach to extending lifespan in C. elegans.
0
False
#8807293 Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation.
0
False
#16720740 daf-16 protects the nematode Caenorhabditis elegans during food deprivation.
0
False
#22265419 HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity.
0
False
#9794765 Extended life-span and stress resistance in the Drosophila mutant methuselah.
0
False
#8582611 Regulation of gene expression is linked to life span in adult Drosophila.
0
False
#22848679 NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.
0
False
#17173038 Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models.
0
False
#16182251 The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging.
0
False
#22754872 Lack of Ach1 CoA-Transferase Triggers Apoptosis and Decreases Chronological Lifespan in Yeast.
0
False
#12736687 Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.
0
False
#20947565 Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae.
0
False
#11000115 Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
0
False
#18690010 A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery.
0
False
#11292860 Regulation of longevity and stress resistance by Sch9 in yeast.
0
False
#22846641 Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz.
0
False
#22843669 D-chiro-Inositol and Pinitol Extend the Life * Span of Drosophila melanogaster.
0
False
#22844336 The Yang-Tonifying Herbal Medicine Cynomorium songaricum Extends Lifespan and Delays Aging in Drosophila.
0
False
#22829775 Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.
0
False
#20477758 Trehalose extends longevity in the nematode Caenorhabditis elegans.
0
False
#11410594 Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span.
0
False
#15141092 Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging.
0
False
#17662940 Type 5 adenylyl cyclase disruption increases longevity and protects against stress.
0
False
#22790951 New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound.
0
False
#22783207 Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration.
0
False
#22912585 Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes.
0
False
#22824366 Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans.
0
False
#22810224 Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans.
0
False
#22768380 Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.
0
False
#14668850 Genetics: influence of TOR kinase on lifespan in C. elegans.
0
False
#10580504 The p66shc adaptor protein controls oxidative stress response and life span in mammals.
0
False
#20075862 Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway.
0
False
#12383511 Cytoplasmic SIR2 homologue overexpression promotes survival of Leishmania parasites by preventing programmed cell death.
0
False
#19266076 Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.
0
False
#2999848 A 1100-bp sequence of mitochondrial DNA is involved in senescence process in Podospora: study of senescent and mutant cultures.
0
False
#22156391 Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression.
0
False
#10330149 Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina.
0
False
#22170153 Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan.
0
False
#12031907 Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica.
0
False
#11121722 Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins.
0
False
#21455602 Prolongevity effects of a botanical with oregano and cranberry extracts in Mexican fruit flies: examining interactions of diet restriction and age.
0
False
#19906819 Prolongevity effects of an oregano and cranberry extract are diet dependent in the Mexican fruit fly (Anastrepha ludens).
0
False
#19264118 The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly.
0
False
#18346215 Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients.
0
False
#19716408 Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens.
0
False
#19774093 Adult diet affects lifespan and reproduction of the fruit-feeding butterfly Charaxes fulvescens.
0
False
#20609276 Effect of adult chill treatments on recovery, longevity and flight ability of Queensland fruit fly, Bactrocera tryoni (Froggatt) (Diptera: Tephritidae).
0
False
#22094291 Additive and interactive effects of nutrient classes on longevity, reproduction, and diet consumption in the Queensland fruit fly (Bactrocera tryoni).
0
False
#21904823 Protein:carbohydrate ratios explain life span patterns found in Queensland fruit fly on diets varying in yeast:sugar ratios.
0
False
#19558564 Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni).
0
False
#21742024 Life-extending dietary restriction and ovariectomy result in similar feeding rates but different physiologic responses in grasshoppers.
0
False
#18761078 Protein accumulation underlying lifespan extension via ovariectomy in grasshoppers is consistent with the disposable soma hypothesis but is not due to dietary restriction.
0
False
#19129143 Significant effects of Pgi genotype and body reserves on lifespan in the Glanville fritillary butterfly.
0
False
#20072627 Synergistic and additive effects of epigallocatechin gallate and digitonin on Plasmodium sporozoite survival and motility.
0
False
#18434714 Genetic suppression of GH-IGF-1 activity, combined with lifelong caloric restriction, prevents age-related renal damage and prolongs the life span in rats.
0
False
#12668588 Hypotension and reduced catecholamines in neuropeptide Y transgenic rats.
0
False
#12692087 Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction.
0
False
#12057928 Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model.
0
False
#11718806 The Snell dwarf mutation Pit1(dw) can increase life span in mice.
0
False
#22661501 A persistent level of Cisd2 extends healthy lifespan and delays aging in mice.
0
False
#22291164 Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
0
False
#9371826 A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse).
0
False
#22367546 The sirtuin SIRT6 regulates lifespan in male mice.
0
False
#16195414 Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.
0
False
#17973971 Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression.
0
False
#6608731 Effects of food restriction on aging: separation of food intake and adiposity.
0
False
#17923673 Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.
0
False
#15153176 Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer.
0
False
#11331780 Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan.
0
False
#11780111 p53 mutant mice that display early ageing-associated phenotypes.
0
False
#10089885 Longevity, stress response, and cancer in aging telomerase-deficient mice.
0
False
#7493016 Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase.
0
False
#14679299 Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging.
0
False
#19776219 Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.
0
False
#10638529 AlphaMUPA mice: a transgenic model for increased life span.
0
False
#19633237 Overexpression of Mn superoxide dismutase does not increase life span in mice.
0
False
#19487311 Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span.
0
False
#15105378 Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.
0
False
#9060969 Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity.
0
False
#11606777 Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals.
0
False
#19797661 Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
0
False
#15208629 BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.
0
False
#15289464 Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells.
0
False
#10719757 Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice.
0
False
#15879174 Extension of murine life span by overexpression of catalase targeted to mitochondria.
0
False
#21422498 RasGrf1 deficiency delays aging in mice.
0
False
#19717971 Cisd2 mediates mitochondrial integrity and life span in mammals.
0
False
#19451219 Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice.
0
False
#22028811 A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice.
0
False
#15498882 Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.
0
False
#21079617 No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight.
0
False
#16682650 Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction.
0
False
#19880816 Disruption of the mGsta4 gene increases life span of C57BL mice.
0
False
#12543978 Extended longevity in mice lacking the insulin receptor in adipose tissue.
0
False
#22461615 Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
0
False
#21109196 Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration.
0
False
#22253967 Dietary calcium and dairy modulation of oxidative stress and mortality in aP2-agouti and wild-type mice.
0
False
#16123266 Suppression of aging in mice by the hormone Klotho.
0
False
#12483226 IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
0
False
#12933651 Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.
0
False
#11371619 Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production.
0
False
#8100276 Premature ageing in transgenic mice expressing different growth hormone genes.
0
False
#20080168 Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet.
0
False
#1712294 The ovo gene of Drosophila encodes a zinc finger protein required for female germ line development.
0
False
#16000018 Calories do not explain extension of life span by dietary restriction in Drosophila.
0
False
#22771817 Fertility/longevity trade-offs under limiting-male conditions in mating populations of Caenorhabditis elegans.
0
False
#20112046 Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity.
0
False
#15331597 Decreased lifespan in the absence of expression of the mitochondrial small heat shock protein Hsp22 in Drosophila.
0
False
#17592126 Ceramide transfer protein function is essential for normal oxidative stress response and lifespan.
0
False
#17368005 Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan.
0
False
#18955126 Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity.
0
False
#18216496 Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis.
0
False
#18056421 Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila.
0
False
#9363888 Chaperoning extended life.
0
False
#8987567 Microgravity effects on Drosophila melanogaster behavior and aging. Implications of the IML-2 experiment.
0
False
#21319854 Apple polyphenols extend the mean lifespan of Drosophila melanogaster.
0
False
#22197903 Blueberry extract prolongs lifespan of Drosophila melanogaster.
0
False
#14677635 Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster.
0
False
#20367621 Biomarkers of aging in Drosophila.
0
False
#14500985 Demography of dietary restriction and death in Drosophila.
0
False
#22570630 Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality.
0
False
#22768842 Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster.
0
False
#17011021 Comparison between the effects of aging and hyperoxia on glutathione redox state and protein mixed disulfides in Drosophila melanogaster.
0
False
#10506576 Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia.
0
False
#12456885 RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress.
0
False
#11113599 Targeted neuronal gene expression and longevity in Drosophila.
0
False
#22310715 Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila.
0
False
#12620118 A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes.
0
False
#22672579 Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster.
0
False
#20655917 The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO.
0
False
#19409408 Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.
0
False
#18458334 Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila.
0
False
#22737247 Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.
0
False
#20036725 Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22.
0
False
#11408621 Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles.
0
False
#11867705 High-quality life extension by the enzyme peptide methionine sulfoxide reductase.
0
False
#21376794 Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz.
0
False
#8183891 Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster.
0
False
#15533947 DNA methyltransferase gene dDnmt2 and longevity of Drosophila.
0
False
#15308776 Multiple-stress analysis for isolation of Drosophila longevity genes.
0
False
#16581513 Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila.
0
False
#16581512 Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan.
0
False
#15708981 Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
0
False
#11868902 Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies.
0
False
#12610309 Steroid control of longevity in Drosophila melanogaster.
0
False
#2508089 Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.
0
False
#20422037 Carbon dioxide sensing modulates lifespan and physiology in Drosophila.
0
False
#11454765 High-frequency generation of conditional mutations affecting Drosophila melanogaster development and life span.
0
False
#20600782 Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.
0
False
#15954861 Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila.
0
False
#20453260 Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila.
0
False
#12598614 blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.
0
False
#17435236 Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.
2
True
#14602080 JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.
0
False
#15659213 Drosophila longevity is not affected by heterochromatin-mediated gene silencing.
0
False
#12882356 The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico.
0
False
#16300483 Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction.
0
False
#11292875 A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
0
False
#17921418 Optimization of dietary restriction protocols in Drosophila.
0
False
#17266676 The functional costs and benefits of dietary restriction in Drosophila.
0
False
#19823937 Combined effects of suppressing live yeast and of a cold pretreatment on longevity, aging and resistance to several stresses in Drosophila melanogaster.
0
False
#19666103 Contrasted effects of suppressing live yeast from food on longevity, aging and resistance to several stresses in Drosophila melanogaster.
0
False
#15547319 D-galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress.
0
False
#19408653 [Changes of the life span and certain biochemical indexes on Drosophila melanogaster by ethanol exposure].
0
False
#19828196 Cerium caused life span shortening and oxidative stress resistance in Drosophila melanogaster.
0
False
#18245758 The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress.
0
False
#21406223 Nectarine promotes longevity in Drosophila melanogaster.
0
False
#19841272 Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan.
0
False
#9226628 Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster.
0
False
#17056793 Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance.
0
False
#17709434 Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patterns.
0
False
#15542350 Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster.
0
False
#22042724 Balance between macronutrients affects life span and functional senescence in fruit fly Drosophila melanogaster.
0
False
#18268352 Lifespan and reproduction in Drosophila: New insights from nutritional geometry.
0
False
#15236760 Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity.
0
False
#3113991 Successful selection for increased longevity in Drosophila: analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity.
0
False
#11250117 Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster.
0
False
#15288688 Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster.
0
False
#17874997 Dietary restriction alters demographic but not behavioral aging in Drosophila.
0
False
#20333234 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.
0
False
#21443682 dFOXO-independent effects of reduced insulin-like signaling in Drosophila.
0
False
#21518241 Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan.
0
False
#19895881 Food presentation modifies longevity and the beneficial action of dietary restriction in Drosophila.
0
False
#16256171 Drosophila diet restriction in practice: do flies consume fewer nutrients?
0
False
#17125951 Counting calories in Drosophila diet restriction.
0
False
#19798443 Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila.
0
False
#20096722 Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster.
0
False
#22291607 Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis.
0
False
#22653297 Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila.
0
False
#17875315 Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans.
0
False
#22363408 Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila.
0
False
#19720829 JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.
0
False
#19420297 Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions.
0
False
#14734639 Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress.
0
False
#15491684 Doxycycline-regulated over-expression of hsp22 has negative effects on stress resistance and life span in adult Drosophila melanogaster.
0
False
#18796296 The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila.
0
False
#19428445 Neuronal susceptibility to GRIM in Drosophila melanogaster measures the rate of genetic changes that scale to lifespan.
0
False
#22227001 Loss of circadian clock accelerates aging in neurodegeneration-prone mutants.
0
False
#20157575 The circadian clock gene period extends healthspan in aging Drosophila melanogaster.
0
False
#20089120 Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan.
0
False
#20435911 Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.
0
False
#15466435 Longevity and metabolism in Drosophila melanogaster: genetic correlations between life span and age-specific metabolic rate in populations artificially selected for long life.
0
False
#11430488 Genetic analysis of extended lifespan in Drosophila melanogaster III. On the relationship between artificially selected and wild stocks.
0
False
#11121683 Postponed aging and desiccation resistance in Drosophila melanogaster.
0
False
#18053668 Interactions between injury, stress resistance, reproduction, and aging in Drosophila melanogaster.
0
False
#20838645 A naturally occurring polymorphism at Drosophila melanogaster Lim3 Locus, a homolog of human LHX3/4, affects Lim3 transcription and fly lifespan.
0
False
#19840842 Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects.
0
False
#20157574 Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.
0
False
#18221413 Drosophila lifespan control by dietary restriction independent of insulin-like signaling.
0
False
#17465980 Dynamics of the action of dFOXO on adult mortality in Drosophila.
0
False
#19385039 Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan.
0
False
#18434551 Drosophila germ-line modulation of insulin signaling and lifespan.
0
False
#19005568 Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs.
0
False
#21108726 Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor.
0
False
#21415465 Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster.
0
False
#12072463 Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster.
0
False
#9858546 FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies.
0
False
#15130751 Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span.
0
False
#17349761 Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone.
0
False
#20157509 A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila.
0
False
#20003237 Identifying sexual differentiation genes that affect Drosophila life span.
0
False
#15834144 Survival analysis of life span quantitative trait loci in Drosophila melanogaster.
0
False
#16702433 High-resolution mapping of quantitative trait loci affecting increased life span in Drosophila melanogaster.
0
False
#11063689 Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster.
0
False
#15379853 Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan.
0
False
#15013662 Quantitative trait loci affecting natural variation in Drosophila longevity.
0
False
#20686706 Quantitative and molecular genetic analyses of mutations increasing Drosophila life span.
0
False
#10638525 Stress resistance and longevity in selected lines of Drosophila melanogaster.
0
False
#10995037 Oxidative stress resistance: a robust correlated response to selection in extended longevity lines of Drosophila melanogaster?
0
False
#16518700 Resistance to oxidative stress induced by paraquat correlates well with both decreased and increased lifespan in Drosophila melanogaster.
0
False
#16026335 Calorie restriction delays lipid oxidative damage in Drosophila melanogaster.
0
False
#15328413 An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster.
0
False
#12521602 Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity.
0
False
#1379030 The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster.
0
False
#8442664 Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster.
0
False
#20946987 TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance.
0
False
#16099946 The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span.
0
False
#21339330 Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
0
False
#15253933 The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.
0
False
#16377915 Lifespan extending activity of substances secreted by the nematode Caenorhabditis elegans that include the dauer-inducing pheromone.
0
False
#19801973 Induction of autophagy by spermidine promotes longevity.
0
False
#18314552 Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans.
0
False
#8473689 Oxygen-dependent perturbation of life span and aging rate in the nematode.
0
False
#22792076 TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.
0
False
#17673661 Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.
0
False
#18358814 Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
0
False
#19049972 Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.
0
False
#17276341 RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination.
0
False
#21129974 MicroRNAs both promote and antagonize longevity in C. elegans.
2
False
#18331616 Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.
0
False
#16380712 Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.
0
False
#16741121 Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans.
0
False
#21803287 Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.
0
False
#16103914 New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen.
0
False
#21834846 The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner.
0
False
#22570628 The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity.
0
False
#20555324 Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans.
0
False
#22012258 Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.
0
False
#16673436 Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis.
0
False
#17934462 DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.
0
False
#10545213 Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster.
0
False
#17592521 Involvement of genes required for synaptic function in aging control in C. elegans.
0
False
#11063684 Dauer formation induced by high temperatures in Caenorhabditis elegans.
0
False
#10377425 Neurosecretory control of aging in Caenorhabditis elegans.
0
False
#16054097 C. elegans tubby regulates life span and fat storage by two independent mechanisms.
0
False
#16244463 Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans.
0
False
#8807294 A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans.
0
False
#10638523 The spe-10 mutant has longer life and increased stress resistance.
0
False
#15068796 C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.
0
False
#12620193 Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans.
0
False
#7934213 Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans.
0
False
#8350650 The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development.
0
False
#8169328 The effects of temperature on the longevity of a radiation-sensitive mutant rad-8 of the nematode Caenorhabditis elegans.
0
False
#19713489 Starvation protects germline stem cells and extends reproductive longevity in C. elegans.
0
False
#10364160 A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
0
False
#15719061 Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans.
0
False
#16373574 A developmental timing microRNA and its target regulate life span in C. elegans.
0
False
#17189267 Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans.
0
False
#11274053 Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
0
False
#9716135 A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.
0
False
#20369008 Phenotypic covariance of longevity, immunity and stress resistance in the caenorhabditis nematodes.
0
False
#18728385 The effects of p53 on whole organism longevity are mediated by autophagy.
0
False
#11591319 The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans.
0
False
#17895432 Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity.
0
False
#18538371 Repeated temperature fluctuation extends the life span of Caenorhabditis elegans in a daf-16-dependent fashion.
0
False
#11445592 Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans.
0
False
#8601482 The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.
0
False
#11782415 DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity.
0
False
#11799246 Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.
0
False
#11959102 Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75.
0
False
#19467242 C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response.
0
False
#12750521 Regulation of aging and age-related disease by DAF-16 and heat-shock factor.
0
False
#22360389 Temporal requirements of heat shock factor-1 for longevity assurance.
0
False
#14668486 Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.
0
False
#16917064 Mutations that increase the life span of C. elegans inhibit tumor growth.
0
False
#10819307 Defining wild-type life span in Caenorhabditis elegans.
0
False
#18056973 Sex-specific effects of the DAF-12 steroid receptor on aging in Caenorhabditis elegans.
0
False
#926867 Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span.
0
False
#10360574 Signals from the reproductive system regulate the lifespan of C. elegans.
0
False
#11747825 daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.
0
False
#10747056 Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans.
0
False
#19662517 Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans.
0
False
#8325483 Absence of strong heterosis for life span and other life history traits in Caenorhabditis elegans.
0
False
#10708258 Isolating aging mutants: a novel method yields three strains of the nematode Caenorhabditis elegans with extended life spans.
0
False
#6632998 A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results.
0
False
#17335870 The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival.
0
False
#17521386 Longevity determined by developmental arrest genes in Caenorhabditis elegans.
0
False
#10873623 Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans.
0
False
#10335847 A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.
0
False
#11242085 Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
0
False
#17339638 A demographic analysis of the fitness cost of extended longevity in Caenorhabditis elegans.
0
False
#16435200 Deletion of the Caenorhabditis elegans homologues of the CLN3 gene, involved in human juvenile neuronal ceroid lipofuscinosis, causes a mild progeric phenotype.
0
False
#22509016 Midlife gene expressions identify modulators of aging through dietary interventions.
0
False
#17266679 Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.
0
False
#12471266 Rates of behavior and aging specified by mitochondrial function during development.
0
False
#12136014 Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.
0
False
#17411345 Lifespan regulation by evolutionarily conserved genes essential for viability.
0
False
#18836529 A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans.
0
False
#19627265 Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1.
0
False
#19812672 Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans.
0
False
#22185090 Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.
0
False
#17020605 Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling.
0
False
#20178781 Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan.
0
False
#20620993 EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity.
0
False
#18241854 Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity.
0
False
#21533078 PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.
0
False
#22577361 A role for SKN-1/Nrf in pathogen resistance and immunosenescence in Caenorhabditis elegans.
0
False
#12954481 Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans.
0
False
#18457595 Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans.
0
False
#18083317 Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes.
0
False
#20862312 ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans.
0
False
#8638122 Determination of life-span in Caenorhabditis elegans by four clock genes.
0
False
#14678010 Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans.
0
False
#18043747 DAF-2/insulin-like signaling in C. elegans modifies effects of dietary restriction and nutrient stress on aging, stress and growth.
0
False
#12480943 Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span.
0
False
#9725835 Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.
0
False
#21779524 High glucose diets shorten lifespan of Caenorhabditis elegans via ectopic apoptosis induction.
0
False
#9020081 Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.
0
False
#7789761 Genes that regulate both development and longevity in Caenorhabditis elegans.
0
False
#21186286 A potential biochemical mechanism underlying the influence of sterol deprivation stress on Caenorhabditis elegans longevity.
0
False
#11487591 Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects.
0
False
#19747231 Mortality shifts in Caenorhabditis elegans: remembrance of conditions past.
0
False
#3473482 Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans.
0
False
#2392681 Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging.
0
False
#3385139 Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene.
0
False
#11470134 Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans.
0
False
#18693219 The U-shaped response of initial mortality in Caenorhabditis elegans to mild heat shock: does it explain recent trends in human mortality?
0
False
#16826446 Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments.
0
False
#19580861 Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.
0
False
#8608934 A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.
0
False
#10219000 Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans.
0
False
#8700226 A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.
0
False
#11511092 Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans.
0
False
#9183440 Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity.
0
False
#11136229 A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants.
0
False
#10202142 CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans.
0
False
#17318365 Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster.
0
False
#11909680 Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin.
0
False
#12690206 DAF-16 target genes that control C. elegans life-span and metabolism.
0
False
#17608836 Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan.
0
False
#18006689 Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
0
False
#18419309 Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.
0
False
#21614175 The lin-4 Gene Controls Fat Accumulation and Longevity in Caenorhabditis elegans.
0
False
#21765926 Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms.
0
False
#19164523 The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.
0
False
#18536978 Plant adaptogens increase lifespan and stress resistance in C. elegans.
0
False
#12882326 Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals.
0
False
#20528576 A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans.
0
False
#20828537 Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16.
0
False
#19597959 Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1.
0
False
#21938067 Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.
0
False
#20717869 Procyanidins from apples (Malus pumila Mill.) extend the lifespan of Caenorhabditis elegans.
0
False
#15254550 Sirtuin activators mimic caloric restriction and delay ageing in metazoans.
0
False
#16256736 A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.
0
False
#16777605 C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.
0
False
#16280150 Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.
0
False
#16860373 C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.
0
False
#9434744 Targeted gene disruption of the Caenorhabditis elegans L-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes.
0
False
#19370397 Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16.
0
False
#20209166 WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.
0
False
#22279556 Caenorhabditis elegans battling starvation stress: low levels of ethanol prolong lifespan in L1 larvae.
0
False
#17187774 The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy.
0
False
#21695191 The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans.
0
False
#18988854 Fat metabolism links germline stem cells and longevity in C. elegans.
0
False
#18033297 An antidepressant that extends lifespan in adult Caenorhabditis elegans.
0
False
#18219227 Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.
0
False
#20179756 Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways.
0
False
#20925017 Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans.
0
False
#22422488 L: -Theanine extends lifespan of adult Caenorhabditis elegans.
0
False
#21932172 Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species.
0
False
#21264793 The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans.
0
False
#17711560 Caenorhabditis elegans integrates food and reproductive signals in lifespan determination.
0
False
#19112515 Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans.
0
False
#19686215 A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans.
0
False
#20550516 Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity.
0
False
#21331044 Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.
0
False
#19279398 Autophagy genes mediate the effect of calcineurin on life span in C. elegans.
0
False
#15820683 JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.
0
False
#16751106 A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
0
False
#22156377 Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor.
0
False
#21533182 Variable pathogenicity determines individual lifespan in Caenorhabditis elegans.
0
False
#12618395 Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms.
0
False
#17157356 Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal.
0
False
#16164425 Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.
0
False
#16300482 Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.
0
False
#19360094 Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance.
0
False
#21386131 Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants.
0
False
#19764929 Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan.
0
False
#8307318 Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci.
0
False
#8934875 Defining genes that govern longevity in Caenorhabditis elegans.
0
False
#22303358 A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat.
0
False
#17187771 Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans.
0
False
#17476212 PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
0
False
#17538612 Two neurons mediate diet-restriction-induced longevity in C. elegans.
0
False
#19489741 Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans.
0
False
#19793063 Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway.
0
False
#17900900 An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.
0
False
#16626391 Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways.
0
False
#15574588 The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.
0
False
#15837805 Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression.
0
False
#16626392 The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms.
0
False
#19469880 Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans.
0
False
#17204841 Autophagy regulates ageing in C. elegans.
0
False
#21906946 Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.
0
False
#17912023 Autophagy is required for dietary restriction-mediated life span extension in C. elegans.
0
False
#18282106 A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.
0
False
#20590843 Redox regulation, gene expression and longevity.
0
False
#22103665 Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan.
0
False
#9504918 An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.
0
False
#20952811 Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans.
0
False
#9353126 The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
0
False
#18772467 Protein-repair and hormone-signaling pathways specify dauer and adult longevity and dauer development in Caenorhabditis elegans.
0
False
#16164423 LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans.
0
False
#21695230 Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.
0
False
#11740945 A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span.
0
False
#17900898 The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.
0
False
#18692520 Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?
0
False
#18782349 The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans.
0
False
#18024103 Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin.
0
False
#21855561 Curcumin-mediated lifespan extension in Caenorhabditis elegans.
0
False
#17096597 p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.
0
False
#21503726 Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans.
0
False
#19923212 The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity.
0
False
#22452899 Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans.
0
False
#14996832 Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans.
0
False
#21858156 Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans.
0
False
#19085685 Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans.
0
False
#19061950 Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress.
0
False
#22013497 Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans.
0
False
#20700440 RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.
0
False
#21884719 Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway.
0
False
#17914900 Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans.
0
False
#20332814 Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion.
0
False
#21055415 Regulation of longevity by genes required for the functions of AIY interneuron in nematode Caenorhabditis elegans.
0
False
#21713031 The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans.
0
False
#11381260 Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.
0
False
#20824162 The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling.
0
False
#19749979 A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans.
0
False
#21423649 Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans.
0
False
#18423931 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans.
0
False
#21909281 The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.
0
False
#17360327 A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.
0
False
#16530049 SMK-1, an essential regulator of DAF-16-mediated longevity.
0
False
#16563875 Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
0
False
#21749634 The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
0
False
#22505847 A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
0
False
#16530050 Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.
0
False
#19506556 A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
0
False
#20346072 Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans.
0
False
#11709184 Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.
0
False
#11778046 Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.
0
False
#19416129 p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.
0
False
#20172019 A role for p53 in mitochondrial stress response control of longevity in C. elegans.
0
False
#16293572 Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant.
0
False
#15771615 Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans.
0
False
#22253756 Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans.
0
False
#12470895 Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span.
0
False
#18073424 A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.
0
False
#20382831 Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage.
0
False
#18406553 Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans.
0
False
#19197346 Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.
0
False
#21931751 DAF-16 and Δ9 desaturase genes promote cold tolerance in long-lived Caenorhabditis elegans age-1 mutants.
0
False
#19164565 A network biology approach to aging in yeast.
0
False
#20799725 Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast.
0
False
#18500447 Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast.
0
False
#17110466 Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging.
0
False
#19059240 Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast.
0
False
#16806052 MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria.
0
False
#17174052 Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span.
0
False
#16436509 Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging.
0
False
#22445853 Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging.
0
False
#18162582 Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.
0
False
#21707788 Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.
0
False
#16023114 Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes.
0
False
#16527275 Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast.
0
False
#16199065 Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae.
0
False
#17492370 Mutations in the Atp1p and Atp3p subunits of yeast ATP synthase differentially affect respiration and fermentation in Saccharomyces cerevisiae.
0
False
#21906795 Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction.
0
False
#20729566 A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging.
0
False
#15489200 A novel assay for replicative lifespan in Saccharomyces cerevisiae.
0
False
#20093034 Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene.
0
False
#21597195 Anti-aging effects of phloridzin, an apple polyphenol, on yeast via the SOD and Sir2 genes.
0
False
#20550517 Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants.
0
False
#22484922 Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.
0
False
#21371425 GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae.
0
False
#21902802 Sir2 deletion prevents lifespan extension in 32 long-lived mutants.
0
False
#20832724 Elevated histone expression promotes life span extension.
0
False
#15126388 Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism.
0
False
#21700873 Gametogenesis eliminates age-induced cellular damage and resets life span in yeast.
0
False
#19570907 Budding yeast SSD1-V regulates transcript levels of many longevity genes and extends chronological life span in purified quiescent cells.
0
False
#9620775 Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.
0
False
#15621721 Ascorbate restores lifespan of superoxide-dismutase deficient yeast.
0
False
#12020810 Effect of superoxide dismutase deficiency on the life span of the yeast Saccharomyces cerevisiae. An oxygen-independent role of Cu,Zn-superoxide dismutase.
0
False
#10222047 Mitochondrial superoxide decreases yeast survival in stationary phase.
0
False
#9199172 Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast.
0
False
#8647826 Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo.
0
False
#12640455 Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan.
0
False
#10662670 Two paralogs involved in transcriptional silencing that antagonistically control yeast life span.
0
False
#11389927 The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors.
0
False
#11742528 Profiles of random change during aging contain hidden information about longevity and the aging process.
0
False
#11861900 SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases.
0
False
#9789734 Epigenetic stratification: the role of individual change in the biological aging process.
0
False
#19557187 Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae.
0
False
#10230397 Elimination of replication block protein Fob1 extends the life span of yeast mother cells.
0
False
#9275199 Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae.
0
False
#2644196 Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae.
0
False
#21482672 Mediator influences telomeric silencing and cellular life span.
0
False
#12242224 A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae.
0
False
#7806576 Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span.
0
False
#10207108 Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae.
0
False
#1938877 Telomere length constancy during aging of Saccharomyces cerevisiae.
0
False
#11884393 Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.
0
False
#9150138 Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.
0
False
#10430902 Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae.
0
False
#22675632 Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60.
0
False
#19303850 Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis.
0
False
#11290710 The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination.
0
False
#7859289 Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.
0
False
#12562756 Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing.
0
False
#21248481 Cell size and growth rate are major determinants of replicative lifespan.
0
False
#17172436 Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway.
0
False
#9428525 Extrachromosomal rDNA circles--a cause of aging in yeast.
0
False
#9271578 Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.
0
False
#11756539 hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae.
0
False
#2698814 Replication control and cellular life span.
0
False
#10224252 Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae.
0
False
#12024027 Mutations in DNA replication genes reduce yeast life span.
0
False
#10521401 The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
0
False
#10921902 Sip2p and its partner snf1p kinase affect aging in S. cerevisiae.
0
False
#9851878 Role of RAS2 in recovery from chronic stress: effect on yeast life span.
0
False
#9851879 Heat stress-induced life span extension in yeast.
0
False
#8195187 Cloning and characterization of LAG1, a longevity-assurance gene in yeast.
0
False
#8760941 LAG2, a gene that determines yeast longevity.
0
False
#11805047 Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity.
0
False
#19305133 A molecular mechanism of chronological aging in yeast.
0
False
#18423200 Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.
0
False
#21191185 Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast.
0
False
#16741098 Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction".
0
False
#14729974 Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.
0
False
#15547318 The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity.
0
False
#12586694 SOD2 functions downstream of Sch9 to extend longevity in yeast.
0
False
#17482543 Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
0
False
#15020466 Rtg2 protein links metabolism and genome stability in yeast longevity.
0
False
#18628831 Genomic instability is associated with natural life span variation in Saccharomyces cerevisiae.
0
False
#18930829 The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease.
0
False
#10620009 Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast.
0
False
#18195102 Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.
0
False
#19467248 Inactivation of the 20S proteasome maturase, Ump1p, leads to the instability of mtDNA in Saccharomyces cerevisiae.
0
False
#20157595 Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density.
0
False
#21641548 Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.
0
False
#17200108 The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension.
0
False
#18381895 The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast.
0
False
#12855292 The Ras and Sch9 pathways regulate stress resistance and longevity.
0
False
#17710147 DNA replication stress is a determinant of chronological lifespan in budding yeast.
0
False
#14741356 Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae.
0
False
#20622262 Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.
0
False
#18340043 Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.
0
False
#22303396 Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan.
0
False
#11024000 An intervention resembling caloric restriction prolongs life span and retards aging in yeast.
0
False
#12213553 Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast.
0
False
#10512855 Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.
0
False
#17544056 Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span.
0
False
#22615903 Ammonium is toxic for aging yeast cells, inducing death and shortening of the chronological lifespan.
0
False
#21901113 Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.
0
False
#19458476 Autophagy is required for extension of yeast chronological life span by rapamycin.
0
False
#20421943 A microarray-based genetic screen for yeast chronological aging factors.
0
False
#19302372 Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae.
0
False
#21918615 Identification of longevity genes with systems biology approaches.
0
False
#15722108 Genes determining yeast replicative life span in a long-lived genetic background.
0
False
#20657825 Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.
0
False
#18469137 Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span.
0
False
#19424415 Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension.
0
False
#19805817 Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response.
0
False
#18225956 Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9.
0
False
#16418483 Extension of chronological life span in yeast by decreased TOR pathway signaling.
0
False
#22216232 A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae.
0
False
#19030232 Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
0
False
#21447998 A genomic analysis of chronological longevity factors in budding yeast.
0
False
#20713692 Yin and Yang of histone H2B roles in silencing and longevity: a tale of two arginines.
0
False
#16336970 Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence.
0
False
#20707985 Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes.
0
False
#21076178 Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence.
0
False
#20696905 Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity.
0
False
#17460215 Effects of deleting mitochondrial antioxidant genes on life span.
0
False
#16782871 Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span.
0
False
#17403371 Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression.
0
False
#18704665 Increased aerobic metabolism is essential for the beneficial effects of caloric restriction on yeast life span.
0
False
#20640543 Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae.
0
False
#16311627 Increased life span due to calorie restriction in respiratory-deficient yeast.
0
False
#15383542 Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae.
0
False
#21584246 Identification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels.
0
False
#17711561 Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins.
0
False
#18513215 Caffeine extends yeast lifespan by targeting TORC1.
0
False
#22319457 Down-regulating sphingolipid synthesis increases yeast lifespan.
0
False
#16286010 Sir2 blocks extreme life-span extension.
0
False
#15328540 Sir2-independent life span extension by calorie restriction in yeast.
0
False
#21949725 Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast.
0
False
#22438832 The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex.
0
False
#12124627 Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.
0
False
#17129213 Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.
0
False
#16051752 HST2 mediates SIR2-independent life-span extension by calorie restriction.
0
False
#12939617 Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
0
False
#21931558 Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae.
0
False
#12297502 Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.
0
False
#12391171 High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction.
0
False
#12788479 Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells.
0
False
#11744041 Loss of prohibitins, though it shortens the replicative life span of yeast cells undergoing division, does not shorten the chronological life span of G0-arrested cells.
0
False
#12882345 The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells.
0
False
#22622083 Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion.
0
False
#9259555 The prohibitin family of mitochondrial proteins regulate replicative lifespan.
0
False
#15130665 Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death.
0
False
#18059160 Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.
0
False
#17617737 Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila.
0
False
#17392428 Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex.
0
False
#11462771 Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models.
0
False
#18241326 Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response.
0
False
#23066506 The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.
0
False
#16293764 Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
0
False
#None A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila.
0
False
#22366109 Misexpression screen delineates novel genes controlling Drosophila lifespan.
0
False
#23028355 C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.
2
False
#22970337 Apple can act as anti-aging on yeast cells.
0
False
#23144747 Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.
3
True