Denigma: Loss-of-Function

Loss-of-Function (LoF)

Interventions:

synaptobrevin RNAi

beta-transducin RNAi

daf-11 mutation

Germ-cell precursor ablation

daf-14 mutation

Whole-body Sirt1 deletion in the adulthood

rsks-1 mutation

Inhibition of TOR signaling

Defects in the cilia of dendritic nerve endings

HNRNPD deletion

Prkar2b knockout

RPL12B deletion

Heterzygous Rpd3 null mutation

mdt-15 mutation

slcf-1 mutation

unc-51 mutation

ctbp-1 mutation

aPKC transposition

esg transposition

sgg transposition

Replacement of Cebpa by Cebpb

Transient CDC7 inactivation

che-11 mutation

che-13 mutation

Heterzygous chico mutation

daf-10 mutation

Pou1f1 knockout

daf-12 mutation

daf-15 mutation

daf-18 mutation

daf-19 mutation

daf-28 mutation

p53 deletion mutation

Pi3K92E mutation

mld heterozygous mutation

eat-10 mutation

eat-18 mutation

eat-13 mutation

fer-15 mutation

Heterozygous Gh1 anti-sense transgene

Homozygous Gh1 anti-sense transgene

Homozygous GH1 deletion

hypomoprhic hep mutation

hsp-16 overexpression

HSP104 deletion

InRE19/InRp5545 transheterozygous mutation

InrGC25/InrE19 transheterozygous mutation

Heterozyogous fat-specific Insr knockout (FIRKO)

Klotho disruption

lars-2 mutation

Mating type heterozygosity

MSN2 MSN4 double mutation

Grisea mutation

nrh-49 mutation

Heterozyogus Shc1 knockout

Homozygous Shc1 knockout

pept-2 mutation

PLD alpha antisense

Homozygous knock-in of proof-reading deficient Polg

Homozygous Prdx1 knockout

Sod2 homozygous knockout

Sod2 heterozyogous knockout

spe-10 mutation

spe-26 mutation

Overexpression of truncated TLC1

unc-13 mutation

unc-15 mutation

unc-20 mutation

unc-25 mutation

unc-26 mutation

unc-29 mutation

unc-30 mutation

unc-31 mutation

unc-32 mutation

unc-35 mutation

unc-10 mutation

unc-46 mutation

unc-47 mutation

unc-49 mutation

unc-54 mutation

unc-64 mutation

unc-76 mutation

unc-78 mutation

unc-78 mutation

unc-79 mutation

unc-80 mutation

YBR238C deletion

Inhibition of mitochondrial respiration

Gh antagonist overexpression

YBR225W deletion

YDR124W deletion

YDR132C deletion

YDR248C deletion

YDR262W deletion

YDR307W deletion

YER186C deletion

YER187W deletion

YGL235W deletion

YGR071C deletion

YKL069W deletion

YLR422W deletion

YLR460C deletion

YMR010W deletion

YMR018W deletion

YMR166C deletion

YNR066C deletion

YPR011V deletion

CG4389 knockdown

Wings ablation/clipping

SFA1 YHB1 double mutation

FKH1 FKH2 deletion

CYR1 transposition

SCH9 Transposition

hsp-12.6 mutation

ubc-18 mutation

sir-2.1 deletion

daf-16 mutation

CG7834 knockdown

Heterozygous hypomorphic Rpd3 mutation

Homozygous chico mutation

F57A8.4 mutation

unc-17 mutation

ins-35 mutation

Fat-body specific Akh knockdown

Igf1 overexpression

RPL37B deletion

RPS27B deletion

TIF4631 deletion

pck-1 overexpression

C26B2.2 knockout

cdc-25.3 knockout

let-363 mutation

YDL180W deletion

YOL092W deletion

daf-17 mutation

Scgdelta deletion

insc transposition

Hsp22 transposition

dj-1beta mutation

Ilp2/Ilp3/Ilp5 mutation

l(3)DTS3 mutation

pash-1 mutation

Dominant negative Tor

Dominant-negative S6k

lin-14 loss-of-function mutation

mir-71 mutation

mir-246 mutation

mir-239 mutation

mir-14 mutation

mir-58 mutation

mir-61 mir-250(nDf59) mutation

mir-64-66 mir-229(nDf63) mutation

mir-80 mir-227(nDf53); mir-81-82(nDf54)

mir-238 mutation

mir-124 mutation

Arhgap1 knockout

Casp-2 deficiency

Cdkn1a knockout

Efemp1 knockout

ERCC1 and ERCC4 deficieny

p53 dominant negative overexpression

sdhC dominant negative overexpression

Surf1 knockdown

14-3-3epsilon mutation

alpha-Man-I mutation

alpha-Man-I RNAi

Ablation of median neurosecretary cells

CG3776 underexpression

kermit disruption

SNF4Agamma deletion

nhr-62 Mutation

miR-277 inhibition

Comment on This Data Unit

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