|miR-277 inhibition ||Transgenic inhibition of miR-277 with a miRNA sponge construct shortens lifespan . ||Fly ||— ||— ||— |
|Constitutive miR-277 expression ||Constitutive miR-277 expression shortens lifespan and synthetically lethal with reduced insulin signaling, indicating that metabolic control underlies this phenotype . ||Fly ||— ||— ||— |
|Spargel overexpression ||Tissue-specific overexpression of dPGC-1 in stem and progenitor cells within the digestive tract of females flies extends the median and maximum lifespan of females by up to 33% and 37%. Those mutants display a delay in the onset of aging-related changes in the intestine, leading to improved tissue homoeostasis in old flies . ||Fly ||— ||+33 ||+37 |
|Hsp70Ba overexpression ||Hsp70Ba overexpression reduces mean and maximum lifespan up to 30% . ||Fly ||-30 ||— ||-30 |
|Zw overexpression ||Mean lifespan of G6PD overexpressor flies is extended in comparison with driver and responder controls, armadillo-GAL4 (up to 38%), Tubulin-GAL4 (up to 29%), C23-GAL4 (up to 27%), da-GAL4 (up to 24%), D42-GAL4 (up to 18%) and Appl-GAL4 (up to 16%). The maximum lifespan is also increased .
G6PD enzymatic activity as well as levels of NADPH, NADH, and the GSH/GSSG ration are increased . ||Fly ||+16 to + 38 ||— ||— |
|yata mutation ||yata mutation shortens the maximum lifespan by 68% and results in progressive deterioration of the nervous tissues and aberrant accumulation of Sec23 . ||Fly ||— ||— ||-68 |
|snz mutation ||Mutation in snz increases maximum lifespan of both sexes by up to 66%, while the median female lifespan is approximately 85% higher and that of males around 72% . ||Fly ||— ||+72 to +85 ||+66 |
|SNF4Agamma deletion ||Deletion of SNF4Agamma from the first day of the imaginal stage shortens mean lifespan by 23% and causes morphological and behavioural features of premature aging . ||Fly ||-23 ||— ||— |
|Rbp9 mutation ||Rbp9 mutation significantly decreases longevity with a 33% reduction in median lifespan of males . ||Fly ||— ||-33 ||— |
|Pten overexpression ||Increased Pten and 4E-BP activity in muscles is extends the lifespan . ||Fly ||— ||— ||— |
|Prx5 mutation ||dprx5(-/-) null mutants are comparatively more susceptible to oxidative stress, have higher incidence of apoptosis, and a shortened mean lifespan, but thee is no significant difference in maximum lifespan (10% survival) . ||Fly ||— ||— ||— |
|Prx5 overexpression ||Prx5 overexpression causes an increase in mean and median lifespan under normal conditions. It also leads to a small increase in maximum lifespan . ||Fly ||— ||— ||— |
|pex16 mutation ||pex16 mutation lead to a reduced mean lifespan of one-third in females and on-fourth in males. The short lifespan can be rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons .
Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects in the development of the nervous system . ||Fly ||-33 to -75 ||— ||— |
|Nlaz mutation ||Absence of Nlaz, which is homologous to ApoD, results in a reduced lifespan in both sexes. Median lifespan is 30.8% and 22.5% lower in females and males, respectively. Maximum lifespan is reduced by 12% and 30% in females and males . ||Fly ||— ||-22.5 to -30.8 ||-12 to -30 |
|Naam overexpression ||Naam overexpression increases mean and maximum lifespan by 30% in both females and males. The lifespan extension is reversed by Sir2 mutants, indicating the it is dependent on Sir2 . ||Fly ||+30 ||— ||+30 |
|MTF-1 overexpression ||MTF-1 overexpression in either the peripheral nervous system or motorneurons extends both mean and maximum lifespan by 40% in males . ||Fly ||+40 ||— ||+40 |
|Mlp84B RNAi ||RNA interference of Mlp84B specifically in the heart results in bradycardia and heart rythm abnormalities as well as a shorter mean lifespan in males but not in females . ||Fly ||— ||— ||— |
|magu overexpression ||Adult-specific overexpression of magu increases lifespan by 5-30% and modulates late-age fecundity . ||Fly ||+5 to +30 ||— ||— |
|Loco mutation ||Reduced expression of Loco due to hetero-deficient results in a 17-20% longer mean lifespan for both male and females, besides the fact that the homozygous deficiency of loco is lethal. Several of these long-lived mutants are more resistant to stresses such as starvation, oxidation ad heat. Additional mutant have higher Manganese-containing superoxide dismutase (MnSOD) activity, increased fat content an diminished cAMP levels. Loco RGS domain is required for the regulation of longevity as deletion analysis suggest . ||Fly ||+17 to +20 ||— ||— |
|Lnk mutation ||Loss of Lnk function results in increased median (14% in females and 17.5 in males) and maximum lifespan, reduced female fecundity and improves survival under conditions of oxidative stress and starvation. Heterozygousity does not result in any significant differences in lifespan in either males or females. Moreover, lifespan extension in one of the female homozygous mutant is fully rescued by the introduction of a Lnk genomic rescue construct . ||Fly ||— ||-14 to -17.5 ||— |
|LBR overexpression ||Overexpression of Lamin B receptor in the adult muscle and in the abdominal fat body results in a 54% and 46% reduction of mean lifespan, respectively . ||Fly ||— ||— ||— |
|kuk Overexpression ||Overexpression of kugelkern in the adult muscle results in a 60% reduction of mean lifespan . ||Fly ||-60 ||— ||— |
|CG3776 underexpression ||Underexpression of CG3776 (alias Jhebp29) reduces the mean lifespan, where the reduction in males is slightly higher. The lifespan of females and male flies underexpressed CG3776 is reduced by 31.6% and 38.8%, respectively when compared with Oregon R flies ..
||Fly ||-31.6 to -38.8 ||— ||— |
|CG3776 overexpression ||Overexpression of CG3776 (alias Jhebp29) reduces the mean lifespan, where the reduction in males is slightly higher.
The lifespan of female and male flies with overexpressed CG3776 is reduced by 35% and 42.6%, respectively when compared with Oregon R flies .
||Fly ||-35 to -42.6 ||— ||— |
|Ilp2 RNAi ||Ilp2 RNA interference results in a 24% to 47% increase in median lifespan . ||Fly ||— ||+24 to +47 ||— |