Interventions

  • Species: + -
  • name effect species mean median maximum
    lin-4 overexpression Overexpressing lin-4 extends lifespan [16373574]. Worm
    lin-4 mutation Loss-of-function mutation in lin-4 shortens lifespan and accelerated tissue ageing [16373574]. Worm
    alg-1 RNAi Adult-specific knockdown of the C. elegans argonaute-like gene 1 *alg-1* results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. Worm -9.6 to -16.1 -13.7
    jnk-1 overexpression Overexpression of jnk-1 increases lifespan by 40% [15767565; 23097426]. JNK-1 overexpression extends the lifespan in a daf-16-dependent manner. JNK-1 overexpression does not extend the lifespan of animals unable to synthesize miRNAs, i.e. pash-1(mj100) [23097426]. Worm +40
    lin-14 gain-of-function mutation A gain-of-function mutation in lin-14 decreases lifespan [16373574]. Worm
    lin-14 loss-of-function mutation A loss-of-function mutation in lin-14 extends lifespan by 31% [16373574]. lin-14(n719) mutation extends mean and maximum lifespan of control animals by 20 and 67%, respectively [23097426]. The life-extending effects is dependent on daf-16 and hsf-1 [16373574]. Inactivation of lin-14 does not increase the lifespan of pash-1 mutants [23097426]. Worm +20 to +31 +67
    mir-71 mutation Loss-of-function of mir-71 decreases lifespan [21129974]. mir-71 mutants have a reduced lifespan with 40% decrease in mean lifespan. Loss of mir-71 function suppresses the long lifespan of glp-1(e2141) mutants [22482727], Worm -40
    pash-1 mutation pash-1 mutants have a decreased lifespan and display phenotypic and molecular signs of advantaged age earlier. pash-1(mj100) temperature sensitive loss-of-function mutation decreases (at the permissive temperature) mean and maximum lifespan by 31 and 71%, respectively. At the restrictive temperature pash-1 mutants are slightly short-lived with a mean and maximum lifespan reduction by 13 and 54%. Lifespan of pash-1 mutants is reduced by a 24h upshift to 25 degree Celsius at the young adult stage with (36 and 78% reduction mean and maximum lifespan, respectively) [23097426]. The rescue of pash-1 expression all tissues restored almost normal lifespan. Rescue specifically in hypodermis, pharynx muscle, gut had no effect on lifespan. Rescue in body wall muscle marginal extended the lifespan, while rescue specifically in the neurons significantly restored mean but not maximum lifespan. Lifespan was also restored by combined rescue in hypodermis and muscle [23097426]. Worm -31 -71
    pyk-1 mutation pyk-1(ok1754) mutation extends the lifespan and this effect is non-additive with the lifespan extension mediated by DDS treatment [20974969]. Worm
    DDS treatment Treatment with DDS either for the entire lifetime or only during the adult period after the L4 stage extends significantly increases mean and maximum lifespan [20974969] DDS causes the delay of aging, reduces lipofuscin accumulation and decreases the level of a mitochondrial complex as well as lowers oxygen consumption and enhances oxidative stress resistance [20974969]. DDS-conferred lifespan extension is independent of daf-16 and DR (eat-2 mutants) [20974969]. Worm
    fbxa-121 RNAi RNA interference of fbxa-121 in adulthood shortens the extended lifespan of daf-2(mu150) mutants. Only a negligible or small reduction in the lifespan of wild-type worms was observed in knockouts [17392428]. Worm
    Resveratrol supplementation Resveratrol supplementation prolongs the lifespan [15254550; 17460219], but not in any case [17875315]. Worm
    SIR-2.4 overexpression Overexpression of SIR-2.4 does not change the mean or maximum lifespan of wild-type nor the ncreased lifespan of daf-2(e1370) mutants [Tishkoff et al. 2012]. Worm
    sir-2.4 RNAi RNA interference against sir-2.4 does not change the mean or maximum lifespan of wild-type not the increased lifespan of daf-2(e1370) mutants [Tishkoff et al. 2012]. Worm
    let-23 RNAi Postdevelopmental inactivation of let-23 by RNA interference extends the lifespan by 5.6% [New Longevity Regulators]. Worm +5.6
    cku-70 RNAi RNA interference of cku-70 further increases the lifespan of daf-2 mutants. Lifespan of daf-16 mutants is slightly decreased by cku-70 RNAi [16099946]. Worm
    cyp-42A1 RNAi RNA interference of cyp-42A1 decreases median lifespan by 39% in wild type animals, 77% in a daf-2 background and 37% in daf-2/daf-16 double mutants [18006689]. Worm -39
    cyp-33E2 RNAi RNA interference of cyp-33E2 increases mean lifespan by 18% [17608836]. Worm
    cwp-4 RNAi RNA interference of cwp-4 extends lifespan [15998808]. Worm
    cul-1 RNAi RNAi of cul-1 decreases lifespan of daf-2 mutant, but not of wild-type or glp-1 mutant. The CUL-1 complex functions in postmitotic, adult somatic tissues of insulin/insulin-like growth factor-1-signaling mutants to enhance longevity. It may act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO [17392428]. Worm
    cua-1 RNAi RNA interference of cua-1 decreases median lifespan by 12% in wild type animals and 30% in daf-2 mutants. Worm -12
    cst-1 overexpression Overexpression of cst-1 extends lifespan and delays aging in a daf-16-dependent manner [16751106]. Worm
    cst-1 RNAi Knockdown of cst-1 shortens lifespan and accelerates tissue aging [16751106]. Worm
    crn-5 RNAi RNA interference against crn-5 in adulthood results in a 41% increase in mean lifespan [17411345]. Worm +41
    col-93 RNAi RNA interference of col-93 results in extended lifespan [15998808]. Worm
    Interventions are an extension of GenAge and GenDR.