|nhr-62 Mutation ||Mutation in *nhr-62* suppresses the lifespan extension of eat-2(ad465) animals (p<0.001) [Heestand et al. 2013]. ||Worm ||— ||— ||— |
|wrn-1 mutation ||A nonfunctional wrn-1 DNA helicase decreases the lifespan .
The expression of miR-124 in whole wrn-1 mutant worms is significantly reduced .
Supplementation of vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants . ||Worm ||— ||— ||— |
|mir-124 mutation ||Loss of mir-124 increases reactive oxygen species formation and accumulation of the aging marker lipofuscin, reduces whole body ATP levels and results in reduction in lifespan .
Supplementation of vitamin C normalizes the reduced median lifespan of mir-124 mutants . ||Worm ||— ||— ||— |
|mir-80 mir-227(nDf53); mir-81-82(nDf54) ||mir-80 mir-227(nDf53); mir-81-82(nDf54) mutation decreases the mean lifespan by 20% . ||Worm ||-20 ||— ||— |
|mir-64-66 mir-229(nDf63) mutation ||mir-64-66 mir-229(nDf63) mutation decreases the lifespan by 30% . ||Worm ||-30 ||— ||— |
|mir-61 mir-250(nDf59) mutation ||mir-61 mir-250(nDf59) mutation decreases the mean lifespan by 25% . ||Worm ||-25 ||— ||— |
|mir-58 mutation ||mir-58(n4640) mutation decreases the mean lifespan by 20% . ||Worm ||-20 ||— ||— |
|mir-14 mutation ||Mutating mir-14 decreases lifespan in both sexes. mir-14 reduces the mean and maximum lifespan of females by 55 and 36%, respectively, while those of males is reduced by 29 and 21%, respectively . ||Worm ||-29 to -55 ||— ||-21 to -29 |
|mir-239 mutation ||Mutating mir-239 increases mean and maximum lifespan by 12 and 36%, respectively. Lifespan extension by mir-239 loss-of-function requires daf-16 . ||Worm ||+11.8 ||— ||+36.0 |
|mir-246 mutation ||Mutating mir-246 decreases mean and maximum lifespan by 12% . ||Worm ||-11.7 ||— ||-12.0 |
|mir-238 mutation ||Mutating mir-238 decreases mean and maximum lifespan by 18 and 24% . mir-238(n4112) mutation decreases mean lifespan by 20% . ||Worm ||-17.6 to -20 ||— ||-24 |
|lin-4 mutation ||Loss-of-function mutation in lin-4 shortens lifespan and accelerated tissue ageing . ||Worm ||— ||— ||— |
|lin-14 gain-of-function mutation ||A gain-of-function mutation in lin-14 decreases lifespan . ||Worm ||— ||— ||— |
|lin-14 loss-of-function mutation ||A loss-of-function mutation in lin-14 extends lifespan by 31% . lin-14(n719) mutation extends mean and maximum lifespan of control animals by 20 and 67%, respectively .
The life-extending effects is dependent on daf-16 and hsf-1 . Inactivation of lin-14 does not increase the lifespan of pash-1 mutants .
||Worm ||+20 to +31 ||— ||+67 |
|mir-71 mutation ||Loss-of-function of mir-71 decreases lifespan . mir-71 mutants have a reduced lifespan with 40% decrease in mean lifespan. Loss of mir-71 function suppresses the long lifespan of glp-1(e2141) mutants , ||Worm ||-40 ||— ||— |
|pash-1 mutation ||pash-1 mutants have a decreased lifespan and display phenotypic and molecular signs of advantaged age earlier.
pash-1(mj100) temperature sensitive loss-of-function mutation decreases (at the permissive temperature) mean and maximum lifespan by 31 and 71%, respectively. At the restrictive temperature pash-1 mutants are slightly short-lived with a mean and maximum lifespan reduction by 13 and 54%. Lifespan of pash-1 mutants is reduced by a 24h upshift to 25 degree Celsius at the young adult stage with (36 and 78% reduction mean and maximum lifespan, respectively) .
The rescue of pash-1 expression all tissues restored almost normal lifespan. Rescue specifically in hypodermis, pharynx muscle, gut had no effect on lifespan. Rescue in body wall muscle marginal extended the lifespan, while rescue specifically in the neurons significantly restored mean but not maximum lifespan. Lifespan was also restored by combined rescue in hypodermis and muscle . ||Worm ||-31 ||— ||-71 |
|pyk-1 mutation ||pyk-1(ok1754) mutation extends the lifespan and this effect is non-additive with the lifespan extension mediated by DDS treatment . ||Worm ||— ||— ||— |
|cep-1 mutation ||cep-1 mutants live up to 33% longer. which is dependent upon functional daf-16 .
||Worm ||+33 ||— ||— |
|cdc-25.3 knockout ||cdc-25.3 knockout mutants also display increased thermotolerance and a 40% lifespan extension . ||Worm ||+40 ||— ||— |
|C26B2.2 knockout ||C26B2.2 knockout mutations extend lifespan . ||Worm ||— ||— ||— |
|asg-2 mutation ||Knockout mutations in asg-2 result in developmental arrest and increased lifespan . ||Worm ||— ||— ||— |
|PIB1 deletion ||Deletion of PIB1 increases replicative lifespan by 25% in the alpha strain [16293764; 19030232]. ||Worm ||+25 ||— ||— |
|Coq7 overexpression ||Transgenic overexpression of mouse Coq7 reverts the extended lifespan of clk-1 mutants . ||Worm ||— ||— ||— |
|ins-35 mutation ||Mutation of ins-35 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. ins-35(TM290) mutation extends mean, 75%ile, and maximum lifespan by 15-17, 14-23, and 23-24%. Lifespan extension by ins-35 mutation is totally abolished by daf-16 or skn-1 RNAi inactivation eat-2 RNAi further enhances the extension of lifespan by mutation in ins-35 .
Mutation of ins-35 enhances pheromone-induced dauer formation .
||Worm ||+15 to +17 ||— ||+23 to +24 |
|shk-1 mutation ||Mutation of shk-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. shk-1(RB1392) mutation extends mean, 75%ile, and maximum lifespan by 19-22, 19-21, and 20-24%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi shortens the lifespan of shk-1 mutants .
Mutation of shk-1 enhances pheromone-induced dauer formation . ||Worm ||+19 to 22 ||— ||+20 to 24 |