Interventions

  • Species: + -
  • name effect species mean median maximum
    C48E7.2 RNAi RNA interference of C48E7.2 in adulthood results in a 26% increase in mean lifespan [17521386]. Worm +26
    C26B2.2 knockout C26B2.2 knockout mutations extend lifespan [15253933]. Worm
    asg-2 mutation Knockout mutations in asg-2 result in developmental arrest and increased lifespan [11410594]. Worm
    akt-1 RNAi RNA interference of akt-1 leads to lifespan extension [15998808]. Worm
    aco-2 RNAi RNA interference of aco-2 leads to lifespan extension [15998808]. Worm
    PIB1 deletion Deletion of PIB1 increases replicative lifespan by 25% in the alpha strain [16293764; 19030232]. Worm +25
    ins-35 mutation Mutation of ins-35 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. ins-35(TM290) mutation extends mean, 75%ile, and maximum lifespan by 15-17, 14-23, and 23-24%. Lifespan extension by ins-35 mutation is totally abolished by daf-16 or skn-1 RNAi inactivation eat-2 RNAi further enhances the extension of lifespan by mutation in ins-35 [22768380]. Mutation of ins-35 enhances pheromone-induced dauer formation [22768380]. Worm +15 to +17 +23 to +24
    shk-1 mutation Mutation of shk-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. shk-1(RB1392) mutation extends mean, 75%ile, and maximum lifespan by 19-22, 19-21, and 20-24%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi shortens the lifespan of shk-1 mutants [22768380]. Mutation of shk-1 enhances pheromone-induced dauer formation [22768380]. Worm +19 to 22 +20 to 24
    glc-4 mutation Mutation of glc-4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. glc-4(JD31) increases the mean, 75%ile, and maximum lifespan by 13-23, 11-23, 19-34%. Lifespan extension by glc-4 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi further enhances the extension of lifespan by glc-4 mutation [22768380]. Mutation of glc-4 suppresses pheromone-induced dauer formation [22768380]. Worm +13 to +23 +18 to +34
    F57A8.4 mutation Mutation of F57A8.4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. F57A8.4(tm4341) mutation extends the mean, 75%ile, and maximum lifespan by 18-38, 21-25, and 42-68%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of either daf-16 nor skn-1. eat-2 RNAi shortens the lifespan of F57A8.4 mutants [22768380]. Mutation of F57A8.4 suppresses pheromone-induced dauer formation [22768380]. Worm +18 to +38 +42 to +68
    cha-1 mutation Mutation of cha-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. cha-1(TY1652) mutation extends mean, 75%ile, and maximum lifespan by 23, 29, and 38%. The cha-1(PR1152) allele extends mean, 75%ile, and maximum lifespan by 22-49, 18-25, and 11-21%. Lifespan extension by cha-1 mutation is not abolished by daf-16 RNAi inactivation. eat-2 RNAi shortens the lifespan of cha-1 mutants [22768380]. Worm +22 to +49 +11 to +21
    unc-17 mutation Mutation of unc-17 extends lifespan on NGM agar covered with killed or live bacteria. unc-17(CB933) extends mean, 75%ile, and maximum lifespan by 31-79%, 68-89%, and 68-79%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of daf-16, but not skn-1. eat-2 RNAi further enhances the extension of lifespan by mutations of unc-17 [22768380]. Mutation and RNAi of unc-17 suppresses pheromone-induced dauer formation [22768380]. Worm +31 to +79 +68 to +79
    gar-3 mutation Mutation of gar-3 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. gar-3(VC670) mutation extends mean, 75%ile, and maximum lifespan by 5-18, 4-7 and 15-56%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of daf-16, skn-1, or eat-2 [22768380]. Worm +5 to +18 +15 to +56
    tdp-1 mutation tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants [Vaccaro et al. 2012]. Worm
    pha-4 mutation Mutants of pha-4 do not respond to bacterial DR. Therefore, loss of pha-4 completely blocks the response to varying food concentration. Reduction of pha-4 does not suppress the long lifespan of daf-2 mutants or animals with defective electron transport chain [17476212]. IF significantly extends lifespan of pha-4 [19079239]. sDR extends lifespan of mutants with a temperature sensitive allele of pha-4, but not daf-16 RNAi [19239417]. Worm
    wwp-1 RNAi RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [18006689]. Loss of wwp-1 function by RNAi reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. wwp-1 RNAi does not suppress the extended lifespan of isp-1 mutants and has only minor suppressive effects on lifespan of another mitochondrial mutant, clk-1, and in cyc-1 RNAi treated worms. RNAi depletion of wwp-1 has no effect on long lifespan of daf-2 mutants [19553937]. Worm -9
    wwp-1 mutation Loss of wwp-1 function by mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants [19553937]. Worm -9
    ubc-18 mutation Loss of ubc-18 function by mutation reduces lifespan at 25 degree Celsius, but only slightly at 20 degree Celsius [19553937]. Worm
    egl-9 mutation egl-9 deletion does not affect lifespan under AL. Lifespan extension under modified sDR regimen is diminished by egl-9 mutation. egl-9 mutation significantly suppresses the lifespan extension by a strong loss-of-function allele of eat-2. Lifespan extension by deletion mutants of rsks-1 is fully suppressed by egl-9 mutation [19461873]. Worm
    ire-1 mutation ire-1 mutation reduces slightly the lifespan under AL, but reduces significantly the lifespan extension by DR. ire-1 mutant has a significantly reduced slope in mean lifespan versus food concentrations relative to wild-type. ire-1 mutation fully suppresses lifespan extension by hif-1 mutation under AL and DR conditions [19461873]. Worm
    hif-1 mutation hif-1 mutation does not suppress lifespan extension of bDR or eat-2 mutation [19372390]. hif-1 deletion extends lifespan by 24%. hif-1 mutation extends lifespan under AL, but does not further extend lifespan extension under modified sDR. hif-1 mutation does not further extend rsks-1 lifespan. pha-4 RNAi slightly reduces lifespan in wild-type and hif-1 mutants, but hif-1 mutation extends lifespan of animals treated with control or pha-4 RNAi to a similar level [19461873]. Worm
    hsp-12.6 mutation hsp-12.6 loss-of-function mutation significantly extends lifespan under AL and significantly suppresses intermittent fasting (IF)-induced increase in lifespan, to a similar extend to that of daf-16 mutation. The extent of IF-induced longevity in daf-16 hsp-12.6 double mutant is similar to that of single hsp-12.6 or daf-16 mutants. hsp-12.6 and daf-16 function in same signaling pathway [19079239]. Worm
    aak-1 mutation aak-1 does not appear to be required for the control of lifespan [15574588]. Worm
    YLR460C deletion Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. Worm -30
    him-6 RNAi him-6 mutants have a low brood size, a shortened lifespan, and an increased amount of germ-line apoptosis [16181657]. Worm
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    • 25 of 103 interventions
    Interventions are an extension of GenAge and GenDR.