Denigma

Interventions

  • Species: + -
    Budding yeast « 
  • Manipulation: + -
    Gain‑of‑Function «  Mutation «  Knockout (1)   Deletion (1)  
    • name effect species mean median maximum
    TSA1 activating mutation A gain-of-function allele of peroxiredoxin (thioredoxin peroxidase, Tsa1) causes a dominant oxidative stress-resistance and robust premature aging phenotype with reduced mean lifespan. These effect is not provoked by altered Tsa1 levels, nor can it be stimulated by deletion, haploinssufficiency or overexpression of wild-type allele [20729566]. Yeast — — —
    SIR3 activating mutation The S755A allele of SIR3 (which prevents phosphorylation of Sir3) results in a 40% increase in mean and maximum lifespan [12640455]. Yeast +40 — +40
    RPL31A deletion Deletion of RPL31A increases mean replicative lifespan by 45% [16293764]. Mean replicative lifespan increases by 35% in the alpha strain and 50% in a strain [19030232; 18423200]. Mean replicative lifespan of the RPL31A deletion mutant increases by 35% in the ORF collection and by 29% in the remade strain [22377630]. RPL31A deletion increases significantly replicative lifespan [17174052]. Deletion of RPL31A extends replicative lifespan and is not further extended by 0.05% glucose restriction [18423200]. Yeast +29 to +50 — —
    • 3 interventions
    Interventions are an extension of GenAge and GenDR.