|LA treatment ||LA confers a memory effect, by fixing the lifespan of previous feeding regimen. When animals are switched early in life (12 months) from DR to AL and supplemented with α-lipoic acid the DR typical lifespan extension is maintained, but switching early from AL supplemented with α-lipoic acid to DR blocks the lifespan extending effect .
LA exhibits the ability to compensate for age-related, long-term memory deficits in old rats .
||Rat ||— ||— ||— |
|Metformin treatment ||In rats metformine treatment reduces body weight significantly (despite similar food intake) but fails to significantly extend the lifespan at any quantile (25th, 50th, 75th, or 90th), overall or maximum lifespan (p > 0.05) . ||Rat ||— ||— ||— |
|C60-olive oil treatment ||Oral administration of C60 dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) for just about 7 months to rats not only does not entail chronic toxicity but it almost doubles the lifespan. The effects on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress. Dissolved C60 is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours .
C60-olive oil can increase the mean, median and maximum lifespan by 114, 91 and 74%. C60-olive oil extends the lifespan of animals with a probability of 0.999 and 0.995 with respect to water and olive oil treatments, respectively .
The GSSG/GSH ratio of animals treated by C60-oil is significantly less (about twice as less) as compared to controls .
||Rat ||+113.8 ||+90.9 ||+73.7 |
|Olive oil treatment ||Oral treatment with Olive oil (at the age of 10 month for 7 months) increases mean, median and maximum lifespan by 41, 18 and 53%, respectively. Olive oil extends the lifespan with a probability of 0.99 . ||Rat ||+41.4 ||+18.2 ||+52.6 |
|Npy overexpression ||Overexpression of Npy under the control of its own promoter results in increased mean and maximum lifespan. However the observed lifespan extension is relatively small (p = 0.0059 by Wilcoxin test and p = 0.05 by t-test; n = 20) .
The blood pressure of Npy transgenic rats was significantly lower as compared with nontransgenic siblings. Food intake and weight were not significantly different compared to controls . ||Rat ||— ||— ||— |
|Homozygous Gh1 anti-sense transgene ||Animals carrying two copies of a Gh1 anti-sense transgene (tg/tg) have a slighlty shorter lifespan (by 5-10%) compared to -/- animals. tg/tg animals are dwarfs and exhibit reduced levels of serum IGF1 . ||Rat ||-5 to -10 ||— ||— |
|Heterozygous Gh1 anti-sense transgene ||Animals carrying a single copy of an anti-sense Gh1 transgene (tg/-) live on average 7-10% longer. tg/- animals are dwarfs and exhibit reduced levels of serum IGF1 . ||Rat ||+7 to +10 ||— ||— |