Denigma

Interventions

  • Species: + -
    House mouse « 
  • Manipulation: + -
    Mutation «  Overexpression «  Gain‑of‑Function (1)   Loss‑of‑Function (1)   Deletion (1)  
    • name effect species mean median maximum
    Heterozyogus Trp53 truncation mutation Mice heterozyogous for an allele of p53 that removes the 5' portion of the protein demonstrate decreased cancer, permature aging phenotypes, and shortened lifespan in the mixed inbred C57BL/6–129/Sv background. It has been proposed that the this allele of p53 results in increased activity/overexpression [11780111]. Mouse — — —
    Gh antagonist overexpression Overexpression of a growth hormone antagonist (a mutated bovine growth hormone that competes with the endogenous one) has no effect on lifespan [12933651]. Mouse — — —
    • 2 interventions
    Interventions are an extension of GenAge and GenDR.