Interventions

  • Species: + -
  • name effect species mean median maximum
    elo-1 RNAi elo-1 RNAi in the adulthood extends lifespan by 11% [21386131]. Worm +11
    elo-2 RNAi elo-1 RNAi in the adulthood extends lifespan by 8% [21386131]. Worm +8
    fat-4 RNAi fat-4 RNAi in the adulthood extends lifespan by 25% [21386131]. Worm 25
    fat-3 RNAi fat-3 RNAi in the adulthood extends lifespan by 10-15% [19301819]. Worm 10-15
    aak-2 mutation aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant [15574588]. Worm -12 -18
    apr-1 RNAi apr-1 RNAi in the adulthood extends the lifespan [99999999]. Worm
    snap-29 RNAi RNAi against snap-29 starting in the adulthood decreases mean and maximum lifespan by 49 and 72%, respectively [23144747]. Worm -48.6 -72.0
    F35G12.4 RNAi RNAi against F35G12.4 starting in the adulthood decreases the lifespan [New longevity regulators]. Worm
    cdtl-7 RNAi RNAi against cdtl-7 starting in the adulthood decreases mean and maximum lifespan by 22 and 25%, respectively [23144747]. Worm -22.2 -25.0
    vha-2 RNAi RNAi against vha-2 starting in the adulthood decreases the lifespan [New longevity regulators]. Worm
    mtch-1 RNAi RNA interference against mtch-1 post-development extends mean lifespan by 21% [17411345]. mtch-1 RNAi in the adulthood extends the lifespan by 2.4 [New longevity regulators]. Worm +2.4 to 21
    cdc-25.3 RNAi RNA interference against cdc-25.3 extends lifespan [16741121]. cdc-25.3 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    gei-9 RNAi RNA interference against gei-9 increases mean lifespan by 57% [17608836]. Worm
    rpn-11 RNAi rpn-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25%, respectively [23144747]. Worm -19.3 -25.0
    rol-3 RNAi rol-3 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    rab-5 RNAi rab-5 RNAi in the adulthood reduces the lifespan by 38.0% [New longevity regulators]. Worm -38.0
    pkc-3 RNAi pkc-3 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    mex-5 RNAi mex-5 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    his-69 RNAi his-69 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    his-55 RNAi his-55 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    grs-1 RNAi grs-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    F54D5.11 RNAi F54D5.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    F38E11.5 RNAi F38E11.5 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    rpn-7 RNAi rpn-7 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    par-6 RNAi par-6 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
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    • 25 of 693 interventions
    Interventions are an extension of GenAge and GenDR.