Interventions

  • name effect species mean median maximum
    Dgat1 knockout Deficiency in Dagat1 promotes leanless and extends mean, median and oldest 10% survival by 23, 26 and 9% without limiting food intake [22291164]. +23 +26
    daf-28 mutation Semi-dominant mutation in daf-28 increases lifespan by 10-15% [8807293]. The daf-28 mutant is dauer constitutive [8005442]. +10 to +15
    fog-3 mutation The fog-3(q470) allele has no effect on lifespan [11799246]. In fog-3 mutant animals cells that would normally become sperm differentiate into oocytes [7713418].
    PLD alpha antisense Antisense suppression of PLD alpha retards abscisic acid- and ethylene-induced senescence. Leaves detached from PLD alpha-deficient transgenic plants when inbutated in abscisic acid and ethylene exhibit a slower rate of senescence that those from wild-type and transgenic controls. PLD alpha deficient strains are associated with retardation of senescence as evidenced by delayed leaf yellowing, lower ion leakage, greater photosynthetic activity, and higher content of cholorophyl and phospholipids [9437863]. Antisense suppression of PLD alpha does not affect natural plant growth and development [9437863].
    rad-8 mutation Mutation of rad-8 increases lifespan by approximately 30% at 16 degree Celsius but not at 20 degree Celsius [8169328] rad-8 mutants are hypersensitive to UV radiation, but not X-rays or MMS [7152245]
    RAD51 deletion Rad51 mutations result in a 40% reduced mean replicative lifespan in strain PSY316 [10207108]. RAD51 is required for gene conversion, but not for repair of an HO-induced double-stranded break [8692957]. RAD51 deletion decreases formation of extrachromosomal rDNA circles [10207108]. -40
    RIF deletion Deletion of RIF1 decrease replicative lifespan by 40% [9275199]. RIF1 deletion increases telomere silencing and length [8319907; 1577274], and therefore likely recruits SIR2 from rDNA to the telomeres which result in lifespan shortening. The sir4-42 allele suppresses the short lifespan of a RIF1 mutant [9275199]. -40
    SIP2 deletion Deletion of the N-myristoylprotein SIP2 results in reduced resistance to nutrient deprivation and a 60% shorter lifespan accompanied by signs of accelerated aging such as loss of silencing from telomeres and mating loci, redistribution of Sir3 to the nucleolus, progressive sterility, nucleolar fragmentation and enlargement, and accumulation of extrachromosomal rDNA [10921902]. SIP2 deletion increases replicative lifespan by 20% in the alpha strain [19030232]. SIP1 null mutation causes increase in the intracellular ATP and NAD+ levels in both young cells (generation 0-1) and older cells (generation 4), but the increase is greater in older cells [10921902]. -60 to +20
    unc-49 mutation The unc-49(e382) allele has no significant effect on lifespan [9789046]. unc-49 mutants are uncoordinated [4366476].
    WRKY6 deletion Deletion of the WRKY6 promoter results in defects in root and leaf cell senescence [11722756].
    YUH1 deletion Deletion of YUH1 decreases replicative lifespan decreased 30% in the alpha strain [18340043]. -30
    ERCC1 and ERCC4 deficieny ERCC1-ERCC4-deficient mice exhibit signs of premature aging [17183314].
    Fxn disruption Disruption results in reduced lifespan, increased oxidative stress, impaired respiration, and the development of hepatic tumors [16278235].
    kermit disruption The disruption of kermit (alias dGIPC) function results in premature loss of locomotor activity and reduced mean lifespan [21029723].
    git3 deletion git3 encodes a G protein-coupled receptor for glucose. git3 deletion increases chronological lifespan in conditions where glucose consumption is not affected. The anti-aging effect of DR and git3 deletion mutation is accompanied by increased respiration and lower ROS production [19266076].
    git3 constitutive activative mutation Constitutive activation of the G-alpha subunit acting downstream of Git3 accelerates aging and inhibits the effect of DR [19266076].
    sty1 deletion Deleting sty1 cancels out chronological lifespan extension and enhanced heat stress resistance by DR [20075862].
    atf1 deletion Deleting atf1 cancels out DR-mediated chronological lifespan extension and enhanced heat stress resistance[20075862].
    wis1 constitutive active mutation Constitutive active mutation of wis1 extends chronological lifespan and there is no further beneficial effect of DR [20075862].
    pka1 deletion pka1 knockouts exhibits a three-fold increase in chronological lifespan with up to 187% longer maximum lifespan [16822282]. Deleting ser/thr cAMP-activated protein kinase pka1 extends chronological lifespan under normal condition, but there is no additive effect with DR [20075862]. +300 +187
    gpa2 constitutive active mutation Constitutive active mutation of gpa2 (alias git8) decreases chronological lifespan under AL (2% glucose) and almost completely cancels out the lifespan extending effect of DR (0.2% glucose) [19266076].
    ATP2 Deletion ATP2 deletion decreases replicative lifespan by 50% in the alpha strain [18340043]. Yeast
    ATG7 deletion ATG7 deletion reduces chronological lifespan by 70% [19302372]. Yeast
    VPS27 deletion Under starvation conditions VPS27 deletion mutants have a dramatically reduced lifespan [20953148]. Yeast
    SAM1 deletion Deletion of SAM1 increases replicative lifespan by 20% in the alpha strain and 15% in the a strain [18340043]. Yeast +15 to +20
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    • 25 of 627 interventions
    Interventions are an extension of GenAge and GenDR.